EUCTR2017-003180-35-GB
Active, not recruiting
Phase 1
Feasibility study on the effects of postnatal enalapril on maternal cardiovascular function following preterm pre-eclampsia - PICk-UP
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Manchester University NHS Foundation Trust
- Enrollment
- 80
- Status
- Active, not recruiting
- Last Updated
- 7 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Diagnosis of preterm pre\-eclampsia (pPE) in this pregnancy requiring delivery \<37 weeks gestation: new or worsening hypertension \>20 weeks with proteinuria or other features suggestive of PE (abnormal haematological, biochemical parameters, fetal growth restriction and/or low PlGF)
- •Biochemical / haematological cut\-offs:
- •\- Platelet count \<100 x109/L
- •\- Alanine amino transferase \> 50units/L
- •\- Creatinine \>90mmol/L
- •\- Abdominal circumference (AC) / estimated fetal weight (EFW) \<3rd centile
- •\- Or 2 of the following:
- •\- AC/EFW \<10th centile
- •\- AC/EFW crossing centiles by \>2 quartiles
- •\- Cerebroplacental ratio \<5th centile
Exclusion Criteria
- •Inability to consent
- •Known cardiac disease
- •Contraindication to ACE inhibitors
- •Current ACE inhibitor / ARB use
- •Renal artery stenosis
Outcomes
Primary Outcomes
Not specified
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