Effects of Regional Nerve Block on Cancer Recurrence

Not Applicable

• Conditions: Cancer Patient
• Interventions: Other: peripheral Nerve block; Other: Normal saline

• Registration Number: NCT03134430
• Lead Sponsor: Luo Foquan

Brief Summary

It has been reported local anesthetics could inhibit tumor cell proliferation, metastasis and invasion ability，but it is still lack of clinical evidence. Our study aims to explore the effects of regional nerve block on cancer recurrence and the mechanism.

Detailed Description

1. To study the effects of TAP block under ultrasound guide on the recurrence of gastric carcinoma, colon cancer, rectal carcinoma and liver cancer and the underlying mechanisms.

2. To clarify the effects of Lateral thoracic nerve block under ultrasound guide on the recurrence of lung cancer and the underlying mechanisms.

Study Timeline

• Study First Submitted: 2017-03-20
• Study First Submitted QC: 2017-04-27
• Study First Posted: 2017-05-01
• Study Start: 2017-07-10
• Primary Completion: 2018-03-25
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-23
• Last Update Posted: 2018-05-25
• Study Completion: 2023-05-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• Patients with primary cancer undergoing elective surgery under general anesthesia

Exclusion Criteria

• Disagree to participate，drop out,lose track, infectious abdominal wall，abnormal puncture point，coagulation dysfunction，allergy of local anesthetic ，immune disease,cancer metastasis,mental disease, acute and chronic infectious disease or other severe disease.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
peripheral Nerve block	peripheral Nerve block	0.35% ropivacaine and 0.5% lidocaine in normal saline
Normal saline	Normal saline	equal volume of normal saline as treatment group

Primary Outcome Measures

Name	Time	Method
the effect of nerve block on the cancer recurrence rate and survival rate postoperation	up to 5 years after surgery	to trace cancer recurrence after tumor resection with CT scaning and tumor biological maker test for 5 years

Secondary Outcome Measures

Name	Time	Method
the effect of nerve block on the percentage and classification of immunocyte and content of cytokines	at 0h, 24h, 48h after nerve block	percentage and classification of immunocyte will be detected by Use flow cytometry, and cytokines will be detected by ELISA
activity after operation	up to 2 weeks	Observe recovery time of gastrointestinal function and off-bed activity after nerve block
dosage of intraoperative anesthetic	intraoperative period	Record the propofol and remifentanil during the operation
Hospital stay	up to 4 weeks after surgery	Observe length of hospital stay
VAS after operation	at 24h, 48h after nerve block	Assess the visual analogue scale 24，48h after nerve block

Trial Locations

Locations (1)

The first affiliated hospital of nanchang university; 🇨🇳 Nanchang, Jiangxi, China