NCT03134430Unknown不适用
Effects of Regional Nerve Block on Cancer Recurrence
Luo Foquan1 个研究点 分布在 1 个国家目标入组 400 人开始时间: 2017年7月10日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- the effect of nerve block on the cancer recurrence rate and survival rate postoperation
研究概览
简要总结
It has been reported local anesthetics could inhibit tumor cell proliferation, metastasis and invasion ability，but it is still lack of clinical evidence. Our study aims to explore the effects of regional nerve block on cancer recurrence and the mechanism.
详细描述
- To study the effects of TAP block under ultrasound guide on the recurrence of gastric carcinoma, colon cancer, rectal carcinoma and liver cancer and the underlying mechanisms.
- To clarify the effects of Lateral thoracic nerve block under ultrasound guide on the recurrence of lung cancer and the underlying mechanisms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with primary cancer undergoing elective surgery under general anesthesia
排除标准
- •Disagree to participate，drop out,lose track, infectious abdominal wall，abnormal puncture point，coagulation dysfunction，allergy of local anesthetic ，immune disease,cancer metastasis,mental disease, acute and chronic infectious disease or other severe disease.
研究组 & 干预措施
Normal saline
Placebo Comparator
equal volume of normal saline as treatment group
干预措施: Normal saline (Other)
peripheral Nerve block
Active Comparator
0.35% ropivacaine and 0.5% lidocaine in normal saline
干预措施: peripheral Nerve block (Other)
结局指标
主要结局
the effect of nerve block on the cancer recurrence rate and survival rate postoperation
时间窗: up to 5 years after surgery
to trace cancer recurrence after tumor resection with CT scaning and tumor biological maker test for 5 years
次要结局
- activity after operation(up to 2 weeks)
- the effect of nerve block on the percentage and classification of immunocyte and content of cytokines(at 0h, 24h, 48h after nerve block)
- dosage of intraoperative anesthetic(intraoperative period)
- Hospital stay(up to 4 weeks after surgery)
- VAS after operation(at 24h, 48h after nerve block)
研究者
Luo Foquan
Professor
The First Affiliated Hospital of Nanchang University
研究点 (1)
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