Effects of a Peripheral Nerve Block on Biomarkers of Pain and Inflammation

Not Applicable

Completed

• Conditions: Pain

• Registration Number: NCT00780936
• Lead Sponsor: Stanford University

Brief Summary

The purpose of this study is to determine the effect of a local anesthetic nerve block on markers of inflammation and pain after a sunburn. This is important because it may provide information regarding the way that nerve blocks help with the treatment of pain and in particular provide preemptive analgesia.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-10
• Study Completion: 2008-07
• Study First Submitted: 2008-10-24
• Study First Submitted QC: 2008-10-27
• Study First Posted: 2008-10-28
• Status Verified: 2008-11
• Last Update Submitted: 2008-11-21
• Last Update Posted: 2008-11-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

1. Between 18 and 50 years of age 2. Fluent in English language 3. Provide written informed consent 4. Skin pigmentation type II or III


Exclusion Criteria

1. Current use of prescription drugs interfering with study objective 2. Use of over-the-counter analgesic/anti-inflammatory drugs within 48h of study participation 3. Current acute or chronic pain conditions 4. Significant medical conditions including psychiatric, neurological, and dermatological diseases 5. Pregnancy 6. Allergies to study drug(s) 7. Concomitant participation in other study protocol

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Measurement of the effect of a preemptive peripheral nerve block on the hyperalgesic response to an artificially induced sunburn.

Secondary Outcome Measures

Name	Time	Method
Measurement of the effect of a preemptive peripheral nerve block on the release of pro-inflammatory cytokines.

Trial Locations

Locations (1)

Stanford University School of Medicine; 🇺🇸 Stanford, California, United States