NCT00780936已完成不适用
Effect of Peripheral Nerve Block on Inflammatory and Nociceptive Biomarkers in a UV-B Burn Model in Humans
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Measurement of the effect of a preemptive peripheral nerve block on the hyperalgesic response to an artificially induced sunburn.
研究概览
简要总结
The purpose of this study is to determine the effect of a local anesthetic nerve block on markers of inflammation and pain after a sunburn. This is important because it may provide information regarding the way that nerve blocks help with the treatment of pain and in particular provide preemptive analgesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Between 18 and 50 years of age
- •Fluent in English language
- •Provide written informed consent
- •Skin pigmentation type II or III

排除标准
- •Current use of prescription drugs interfering with study objective
- •Use of over-the-counter analgesic/anti-inflammatory drugs within 48h of study participation
- •Current acute or chronic pain conditions
- •Significant medical conditions including psychiatric, neurological, and dermatological diseases
- •Allergies to study drug(s)
- •Concomitant participation in other study protocol
结局指标
主要结局
Measurement of the effect of a preemptive peripheral nerve block on the hyperalgesic response to an artificially induced sunburn.
次要结局
- Measurement of the effect of a preemptive peripheral nerve block on the release of pro-inflammatory cytokines.
研究者
研究点 (2)
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