Passive Smoking and LL-37 in Children

Completed

• Conditions: Periodontal Health; Innate Immunity

• Registration Number: NCT03639376
• Lead Sponsor: Kırıkkale University

Brief Summary

This study investigates the salivary LL-37 in passive smoking-exposed and unexposed children and the association between salivary LL-37 levels and periodontal clinical parameters in these children.Unstimulated salivary samples were collected from 180 children (90 passive smoking-exposed and 90 passive smoking-unexposed)

Detailed Description

Diverse mechanisms conduce to the detrimental periodontal effects of passive smoking, including alteration of both microbial and host response factors.

Antimicrobial peptides are considered to be an important intermediate step in initiating an initial immune response against the microbial side of the oral gingival epithelium and in the transition to acquired immunity.

LL-37 has a wide antimicrobial activity against both cariogenic and periopathogenic bacteria and its role in maintaining oral health has recently been stated

Study Timeline

• Study Start: 2016-11
• Primary Completion: 2018-04
• Study Completion: 2018-06
• Status Verified: 2018-08
• Study First Submitted: 2018-08-16
• Study First Submitted QC: 2018-08-20
• Last Update Submitted: 2018-08-20
• Study First Posted: 2018-08-21
• Last Update Posted: 2018-08-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

• Systemically healthy children

Exclusion Criteria

• Any medications known to affect defense system and periodontium
• The presence of orthodontic / intraoral appliance

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Antimicrobial Peptide	In the first 18 months of study	LL-37 (pg/mL)

Secondary Outcome Measures

Name	Time	Method
Passive smoking measurement	In the first 18 months of study	Cotinine (ng/mL)