Effects of visible light on inflammation and skin barrier recovery following acute perturbatio

Completed

Conditions: skin barrier
stratum corneum
10014982

Registration Number: NL-OMON43517

Lead Sponsor: Philips Research

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 44

Inclusion Criteria

1. skin type I, II or III (Fitzpatrick scale);
2. 18 - 40 years old;
3. willing to give written informed consent

Exclusion Criteria

1. diagnosis of histamine hypersensitivity;
2. presence of cardiac pacemakers or other implanted electric devices;
3. pregnancy or lactation;
4. atopic predisposition (i.e. allergy, atopic/contact dermatitis, hay fever, asthma);
5. any current (skin) disease including conditions causing photosensitivity;
6. predisposition to respond allergic;
7. use of immunosuppressive drugs;
8. use of antihistamines drugs;
9. use of medication for hypertension with airway constricting activity;
10. use of medication with photosensitizing effects;
11. skin type IV, V, VI (Fitzpatrick scale);
12. excessive sun exposure or tanning less than 2 weeks before the beginning of the study.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the recovery of the skin barrier after tape<br /><br>stripping, measured with transepidermal water loss (marker of skin barrier<br /><br>status), and the clearance of inflammation after histamine iontophoresis,<br /><br>measured with a* value (marker of skin redness). Both measurements are<br /><br>non-invasive. Tape stripping and histamine iontophoresis will be performed<br /><br>twice on the same volunteer, on two consecutive weeks. On one occasion<br /><br>stimulation is followed by irradiation, in the other no irradiation is<br /><br>performed serving as control. </p><br>

Secondary Outcome Measures