Macular Hemorrhage in Myopic Eyes

• Conditions: Macula Lutea Hemorrhage; High Myopia

• Registration Number: NCT01943448
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Visual impairment in high myopic eyes is mainly due to the different types of myopic maculopathies, such as diffuse or patchy atrophy, lacquer cracks and choroidal neovascularization. Macular hemorrhage was one of those complications. Despite choroidal neovascularization, simple hemorrhage from rupture of Bruch's membrane and choroidal microcirculation is also the cause of hemorrhage. The prognosis of those eyes with simple hemorrhage is generally good. However, some patients had persistently poor vision after the absorption of the hemorrhage. In the literature, the visual prognosis in those patients was reported to be associated with the microstructure change under the optical coherent tomography (OCT) or the presentation of the autofluorescence. The investigators will collect the patients with high myopia and presenting with macular hemorrhage. High resolution OCT and autofluorescence imaging will be used to analyze the change of the microstructure of retina and its correlation with the visual prognosis.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-08
• Study First Submitted: 2013-09-12
• Study First Submitted QC: 2013-09-16
• Study First Posted: 2013-09-17
• Status Verified: 2014-04
• Last Update Submitted: 2014-04-13
• Last Update Posted: 2014-04-15
• Primary Completion: 2015-05
• Study Completion: 2015-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Myopia more than -6D
• Macular hemorrhage inside arcade
• Patients who are willing to visit our clinic and receive examination regularly for at least 1 year

Exclusion Criteria

• Patients who cannot cooperate.
• Macular hemorrhage unrelated to myopia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
visual acuity	1 year	visual acuity during follow up and its correlation to other factors

Secondary Outcome Measures

Name	Time	Method
Optical coherence tomography	1 year	Change of microstructure of the retina and choroid on OCT during follow up

Trial Locations

Locations (1)

Department of Ophthalmology, National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan