Association Between Retinal Microvasculature and Optic Disc Alterations in Non-pathological High Myopia With OCTA
- Conditions
- Myopia
- Interventions
- Diagnostic Test: Comprehensive ophthalmologic examination
- Registration Number
- NCT04631991
- Lead Sponsor
- Akdeniz University
- Brief Summary
Non-pathological high myopia patients and controls undergoing a comprehensive ophthalmologic examination are included. The Optical Coherence Tomography Angiography (OCTA) software automatically segments these full-thickness retinal scans into the superficial and deep inner retinal vascular plexuses, outer retina, and choriocapillaris (CC). The vascular density in the superficial and deep retinal vascular zones is calculated automatically by the software, and the foveal avascular zone (FAZ) and foveal density (FD) are also automatically determined. Choroidal thickness is calculated manually by two retinal specialists, and the average value was used.
- Detailed Description
Non-pathological high myopia patients and controls undergoing a comprehensive ophthalmologic examination, including measurements of best-corrected visual acuity, refractive error; intraocular pressure, axial length, slit lamp examination of the anterior segment, dilated fundus examination and OCTA imaging are included. The best-corrected visual acuity is convert into the logarithm of minimal angle resolution. The OCTA images are independently graded and assessed by two retinal specialists. The software automatically segmented these full-thickness retinal scans into the superficial and deep inner retinal vascular plexuses, outer retina, and choriocapillaris (CC). The vascular density in the superficial and deep retinal vascular zones is calculated automatically by the software, and the foveal avascular zone (FAZ) and foveal density (FD) are also automatically determined. Choroidal thickness is calculated manually by two retinal specialists, and the average value was used.
Right eye of each participant is included in the study. If the right eye shows any exclusion criteria, then the left eye is selected for enrollment. Eyes with an AL longer than 26 mm are included in the HM group. The classification of myopic maculopathy is applied in identification of fundus alterations. Patients with category 0 (no myopic retinopathy lesions) and category 1 (tessellated fundus) are included in the study.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 70
- Patients with category 0 (no myopic retinopathy lesions)
- Patients with category 1 (tessellated fundus)
- poor image quality (signal strength index (SSI) <60) due to unstable fixation
- IOP >21 mm Hg; logMAR > 0.1
- pre-existing ophthalmic pathologies
- prior ocular surgery
- systemic chronic disease which can cause retinopathy
- such as diabetes mellitus, hypertension etc.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Non-pathological high myopia Comprehensive ophthalmologic examination Comprehensive ophthalmologic examination Control Comprehensive ophthalmologic examination Comprehensive ophthalmologic examination
- Primary Outcome Measures
Name Time Method Optic nerve head vessel density 10 minutes Optic nerve head vessel density assessed with optical coherence tomography angiography
- Secondary Outcome Measures
Name Time Method Choriocapillaris flow area 10 minutes Choriocapillaris flow area assessed with optical coherence tomography angiography
Subfoveal central macular thickness 10 minutes Subfoveal central macular thickness assessed with optical coherence tomography angiography
Subfoveal choroidal thickness 10 minutes Subfoveal choroidal thickness assessed with optical coherence tomography angiography
Foveal avascular zone 10 minutes Foveal avascular zone assessed with optical coherence tomography angiography
Trial Locations
- Locations (1)
Aslı Çentinkaya Yaprak
🇹🇷Antalya, Turkey