Consequences of short-term hypo- and hyperthyroidism on brain structure and function in humans
Not Applicable
- Conditions
- Effects of mild hyper- and hypothyroidism
- Registration Number
- DRKS00011275
- Lead Sponsor
- Klinik für NeurologieUKSH Campus Lübeck
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Hyperthyroidism: healthy volunteers
Hypothyroidism: patients under thyroxine substitution
Exclusion Criteria
any severe general disease, no cardovascular diseases
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cognitive functions were assessed by resting state and functional MRI under short-term memory challenge. Arterial spin labelling, voxel based morphometry as well as a battery of neuropsychological tests (visual analogue scale for hyper- or hypothyroidism, battery for attention testing, attention network task, trail making task, auditory verbal learning test both during euthyroidism and following 8 weeks of alteration of thyroid function as tested by thyroid function tests in the 2 groups of test subjects will be used.
- Secondary Outcome Measures
Name Time Method ew biomarkers derived from serum and plasma samples in parallel to the samples obtained for thyroid function tests will be used. During the alteration of thyroid function but also in the recovery period up to 8 weeks after we will use an unsupervised approach by the help of proteomics and metabolomics techniques.