Reflective Testing for Early Diagnosis of Pituitary Dysfunction

Not Applicable

Withdrawn

• Conditions: Pituitary Dysfunction
• Interventions: Device: Investigation for pituitary dysfunction by blood tests.; Device: Dynamic function tests and pituitary imaging

• Registration Number: NCT02406417
• Lead Sponsor: Nova Scotia Health Authority

Brief Summary

Early detection and management of pituitary dysfunction reduces the morbidity that ensues as a consequence of missed or delayed diagnosis of this condition, and which may result in life-threatening events and increased mortality.

The investigators study will explore the use of reflex strategies within the laboratory in capturing suspicious pituitary function test results from Primary Care patients and following these up with appropriate reflective testing. Subsequently patients identified from these results to have a possible underlying piuitary dysfunction will have an alert sent to their family physician prompting referral to the Endocrine team for further investigation and management.

Detailed Description

Not available

Study Timeline

• Status Verified: 2015-03
• Study Start: 2015-03-01
• Primary Completion: 2015-03-01
• Study Completion: 2015-03-01
• Study First Submitted: 2015-03-02
• Study First Submitted QC: 2015-03-30
• Study First Posted: 2015-04-02
• Last Update Submitted: 2024-08-19
• Last Update Posted: 2024-08-21

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Patients from Primary Care found to have one or more abnormal pituitary function test picked up by the laboratory information system in the Clinical Chemistry laboratory.

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Exclusion Criteria

• Patients with known pituitary dysfunction or on medication that may affect pituitary function tests.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Investigation for pituitary dysfunction	Investigation for pituitary dysfunction by blood tests.	Further investigation for pituitary dysfunction by blood tests, dynamic function tests and pituitary imaging e.g. CT Scan with contrast. Patients identified as being at high risk of having pituitary dysfunction based on preliminary blood tests will have further tests added. If these results point to a likely pituitary dysfunction, the patient will be referred to the Endocrine team for further investigations including dynamic function tests and/or imaging.
Investigation for pituitary dysfunction	Dynamic function tests and pituitary imaging	Further investigation for pituitary dysfunction by blood tests, dynamic function tests and pituitary imaging e.g. CT Scan with contrast. Patients identified as being at high risk of having pituitary dysfunction based on preliminary blood tests will have further tests added. If these results point to a likely pituitary dysfunction, the patient will be referred to the Endocrine team for further investigations including dynamic function tests and/or imaging.

Primary Outcome Measures

Name	Time	Method
Number of patients found to have biochemical evidence of possible pituitary dysfunction	One year

Secondary Outcome Measures

Name	Time	Method
Number of patients from primary outcome found to have true pituitary dysfunction	6- 12 months