Study to Evaluate the Safety and Efficacy of Relamorelin in Participants With Diabetic Gastroparesis Study 02
- Conditions
- GastroparesisDiabetes Mellitus
- Interventions
- Drug: Placebo
- Registration Number
- NCT03426345
- Lead Sponsor
- Allergan
- Brief Summary
This study will evaluate the safety and efficacy of relamorelin compared to placebo in participants with diabetic gastroparesis. Participants will report daily severity scores of their diabetic gastroparesis symptoms.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 311
- Diagnosis of Type 1 or Type 2 diabetes mellitus
- Meet the per protocol criteria of diabetic gastroparesis
- Compliance with diary
- Compliance with the per protocol study treatment dosing instructions
- Currently receiving nutrition intravenously, by nasogastric tube, or other feeding tube
- Actively experiencing anorexia nervosa, binge-eating, bulimia or other eating disorder at the time of Screening (Visit 1)
- Diagnosis of Celiac Disease, also a history of non-celiac gluten sensitivity
- History of gastrointestinal disorders that may be similar to gastroparesis
- Functional dyspepsia diagnosed before the diagnosis of diabetes mellitus
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Following a 2-week placebo run-in, participants received placebo-matching relamorelin injected subcutaneously twice daily for up to 12 weeks. Relamorelin 10 μg Relamorelin Following a 2-week placebo run-in, participants received relamorelin 10 micrograms (μg) injected subcutaneously twice daily for up to 12 weeks.
- Primary Outcome Measures
Name Time Method Change From Baseline to Week 12 in the Weekly Diabetic Gastroparesis Symptom Severity Score (DGSSS) Baseline (Day-14 to Day-1) to Week 12 Participants assessed the severity of diabetic gastroparesis symptoms daily using the Diabetic Gastroparesis Symptom Severity Diary (DGSSD), recorded in an electronic diary (e-diary). The DGSSS was derived as the sum of the weekly averages of the 4 DGSSD items: nausea, abdominal pain, postprandial fullness and bloating. Each symptom was scored using an 11-point ordinal scale where: 0= no or not at all uncomfortable to 10= worst possible or most uncomfortable for a total possible DGSSS of 0 (best) to 40 (worst). A negative change from Baseline indicates improvement. Baseline was defined as the average of the 2 weekly DGSSS from the run-in period.
Percentage of Participants Meeting the Vomiting Responder Criterion During Each of the Last 6 Weeks of the 12-week Treatment Period Week 6 to Week 12 The number of vomiting episodes in the previous 24 hours were assessed daily by the participant using the DGSSD and were recorded in the e-diary. A Vomiting Responder was defined as a participant with zero weekly vomiting episodes during each of the last 6 weeks of the 12-week Treatment Period.
- Secondary Outcome Measures
Name Time Method Percentage of Participants Meeting the Nausea Responder Criterion During Each of the Last 6 Weeks of the 12-week Treatment Period Baseline (Day-14 to Day-1) to (Week 6 to Week 12) A Nausea Responder was defined as a participant with improvement (decrease) of at least 2-points in the weekly symptom scores for nausea at each of the last 6 weeks of the 12-week Treatment Period. Nausea was one of the items of the DGSSD assessed daily and recorded in the e-diary by the participant using an 11-point ordinal scale where: 0= no nausea to 10= worst possible nausea.
Percentage of Participants Meeting the Abdominal Pain Responder Criterion During Each of the Last 6 Weeks of the 12-week Treatment Period Baseline (Day-14 to Day-1) to (Week 6 to Week 12) An Abdominal Pain Responder was defined as a participant with an improvement (decrease) of at least 2-points in the weekly symptom scores for abdominal pain at each of the last 6 weeks of the 12-week Treatment Period. Abdominal pain was one of the items of the DGSSD assessed daily and recorded in the e-diary by the participant using an 11-point ordinal scale where: 0= no abdominal pain to 10= the worst possible abdominal pain and was recorded in an e-diary.
Number of Participants With Potential Clinically Significant (PCS) Clinical Laboratory Results Up to 12 weeks Clinical Laboratory tests included Hematology, Chemistry and Urinalysis tests. The investigator determined if the results were clinically significant. Only those categories where at least 1 person had a non-PCS value at Baseline and met the PCS criterion at least once during postbaseline are reported.
Percentage of Participants Meeting the Bloating Responder Criterion During Each of the Last 6 Weeks of the 12-week Treatment Period Baseline (Day-14 to Day-1) to (Week 6 to Week 12) A Bloating Responder was defined as a participant with an improvement (decrease) of at least 2-points in the weekly symptom scores for bloating at each of the last 6 weeks of the 12-week Treatment Period. Bloating was one of the items of the DGSSD assessed daily and recorded by the participant in the e-diary using an 11-point ordinal scale where: 0= no bloating and 10= the worst possible bloating and was recorded in the e-diary.
Number of Participants Who Experienced One or More Treatment-Emergent Adverse Events (TEAE) Up to approximately 16 weeks An adverse event (AE) is any untoward medical occurrence in a patient or clinical study participant, temporally associated with the use of study treatment, whether or not considered related to the study treatment. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease (new or exacerbated) temporally associated with the use of study treatment. A TEAE is an AE that begins or worsens after receiving study drug.
Number of Participants With Clinically Significant Abnormal Electrocardiogram (ECG) Results Up to 12 weeks A standard 12-lead ECG was performed. The investigator determined if the abnormal results were clinically significant.
Percentage of Participants Meeting the Postprandial Fullness Responder Criterion During Each of the Last 6 Weeks of the 12-week Treatment Period Baseline (Day-14 to Day-1) to (Week 6 to Week 12) A Postprandial Fullness Responder was defined as a participant with an improvement (decrease) of at least 2-points in the weekly symptom scores for Postprandial Fullness at each of the last 6 weeks of the 12-week Treatment Period. Postprandial Fullness was one of the items of the DGSSD assessed daily and recorded by the participant in the e-diary using an 11-point ordinal scale where: 0= no feeling of fullness until finishing a meal (best) to 10= feeling full after only a few bites (worst).
Number of Participants With Anti-relamorelin Antibody Testing Results by Visit Baseline (Day 1), Day 14, Day 28, Day 84, and End of Treatment (Up to Day 84) A blood sample was collected that was sent to a laboratory for an anti-relamorelin antibody screening test. A positive screening test was confirmed by an immunodepletion assay. The number of participants in each of the following categories are reported: Negative Screening Test, Positive Screening Test, Negative Confirmatory Test, and Positive Confirmatory Test at each time point.
Number of Participants With Clinically Meaningful Trends for Vital Signs Up to 12 weeks Vital Signs included assessments of heart rate, respiratory rate, systolic and diastolic blood pressure, and body temperature. The investigator determined if the abnormal results were clinically significant.
Number of Participants With a ≥1% Increase in Glycosylated Hemoglobin A1c (HBA1c) Baseline (Day 1) up to 12 weeks
Trial Locations
- Locations (233)
Atlanta Diabetes Associates
🇺🇸Atlanta, Georgia, United States
Emory University
🇺🇸Atlanta, Georgia, United States
The Ohio State University, Wexner Medical Center
🇺🇸Columbus, Ohio, United States
Aventiv Research, Inc.
🇺🇸Columbus, Ohio, United States
Toronto Western Hospital, University Health Network
🇨🇦Toronto, Ontario, Canada
Gordon and Leslie Diamond Health Care Centre
🇨🇦Vancouver, British Columbia, Canada
Universitair Ziekenhuis Antwerpen, Gastro-Enterologie,
🇧🇪Edegem, Antwerp, Belgium
UZ Brussel
🇧🇪Jette, Brussel, Belgium
Healthy Medical Center
🇨🇴Zipaquira, Cundinamarca, Colombia
Endocare Ltda.
🇨🇴Bogota, Distrito Capital De Bogotá, Colombia
Fundacion Centro de Investigaciones Clinicas CARDIOMET
🇨🇴Pereira, Risaralda, Colombia
Clinicos Asociados BOCM SC
🇲🇽Portales, Distrito Federal, Mexico
Szegedi Tudomanyegyetem
🇭🇺Szeged, Hungary
Synexus Magyarorszag Kft
🇭🇺Zalaegerszeg, Hungary
Kraslava Hospital
🇱🇻Kraslava, Latvia
Centro de Desarrollo Biomedico S.C.P.
🇲🇽Mérida, Yucatan, Mexico
Unidad de Investigación Clínica en Medicina S.C.
🇲🇽Guadalajara, Jalisco, Mexico
Dioderm Instituto de Investigacion
🇲🇽Durango, Mexico
Sociedad de Metabolismo y Corazon, S.C.
🇲🇽Veracruz, Mexico
Hospital Cardiologica Aguascalientes
🇲🇽Aguascalientes, Mexico
Northwestern University Feinberg School of Medicine
🇺🇸Chicago, Illinois, United States
Digestive Disease & Surgery Institute
🇺🇸Cleveland, Ohio, United States
Baylor College of Medicine Medical Center
🇺🇸Houston, Texas, United States
Houston Endoscopy and Research Center, Inc.
🇺🇸Houston, Texas, United States
Rodriguez Clinical Trials
🇺🇸Houston, Texas, United States
Facey Medical Foundation
🇺🇸Mission Hills, California, United States
United Medical Doctors
🇺🇸Murrieta, California, United States
Synexus Clinical Research US, Inc. - Colorado Springs Family Practice
🇺🇸Colorado Springs, Colorado, United States
Angel City Research Inc.
🇺🇸Los Angeles, California, United States
Sanchez Clinical Research, Inc.
🇺🇸Miami, Florida, United States
Torrance Clinical Research Institute, Inc.
🇺🇸Lomita, California, United States
Alabama Medical Group, PC
🇺🇸Mobile, Alabama, United States
Diagnamics Inc.
🇺🇸Encinitas, California, United States
Tri-State Gastroenterology
🇺🇸Crestview Hills, Kentucky, United States
Fresno Clinical Research Center
🇺🇸Fresno, California, United States
Gastroenterology Associates of Fairfield County, P.C.
🇺🇸Bridgeport, Connecticut, United States
Visionary Investigators Network
🇺🇸Aventura, Florida, United States
River Birch Research Alliance, LLC
🇺🇸Blue Ridge, Georgia, United States
Meridian Clinical Research, LLC
🇺🇸Rockville, Maryland, United States
Synexus
🇺🇸Pinellas Park, Florida, United States
Avant Research Associates LLC
🇺🇸Crowley, Louisiana, United States
Oö. Gesundheits- und Spitals-AG/LKH Steyr
🇦🇹Steyr, Austria
Clinica Mayo - Infectious DiseasesClínica Mayo de Urgencias
🇦🇷San Miguel de Tucuman, Tucuman, Argentina
Gastroenterology of Southern Indiana
🇺🇸New Albany, Indiana, United States
Clinical Research Consultants of Atlanta
🇺🇸Suwanee, Georgia, United States
WK Physicians Network
🇺🇸Bossier City, Louisiana, United States
Hospital Sirio Libanes
🇦🇷Caba, Buenos Aires Province, Argentina
Centro de Investigaciones Medicas Mar del Plata SRL
🇦🇷Mar del Plata, Buenos Aires Province, Argentina
Privatklinik Wehrle-Diakonissen
🇦🇹Salzburg, Austria
AZ Sint Lucas Brugge
🇧🇪Brugge, Antwerpen, Belgium
University of Calgary
🇨🇦Calgary, Alberta, Canada
VIVIT Institute, am LKH Feldkirch
🇦🇹Feldkirch, Vorarlberg, Austria
Instituto de Estudos E Persquisas Clinicas do Ceará - IEP/CE - Oncology
🇧🇷Fortaleza, Brazil
Ordination
🇦🇹Sankt Stefan, Steiermark, Austria
Manassas Clinical Research Centre
🇺🇸Manassas, Virginia, United States
The Ottawa Hospital
🇨🇦Ottawa, Ontario, Canada
Maffei Centro Medico-Investigacion Clinica Aplicada
🇦🇷C.a.b.a., Buenos Aires Province, Argentina
Hospital Universitario Walter Cantidio
🇧🇷Fortaleza, Ceara, Brazil
CPQuali Pesquisa Clinica Ltda
🇧🇷Santa Cecília, Sao Paulo, Brazil
Instituto Privado de Investigaciones Clínicas de Córdoba
🇦🇷Córdoba, Cordoba, Argentina
Instituto Catarinense de Endocrinologia e Diabetes (ICED)
🇧🇷Joinville, Santa Catarina, Brazil
Clinical Research Hamburg
🇩🇪Hamburg, Germany
Medplus Mp
🇨🇴Bogota, Distrito Capital De Bogotá, Colombia
Medical and Nutritional Trials
🇲🇽Cuauhtemoc, Cdmx, Mexico
CISSS de la Monteregie-Centre
🇨🇦Greenfield Park, Quebec, Canada
Clinical Research Unit
🇩🇪Giessen, Germany
South Shore Medical Arts
🇨🇦Bridgewater, Nova Scotia, Canada
Asociación Colombiana de Diabetes
🇨🇴Bogotá, Cundinamarca, Colombia
Pauls Stradins Clinical University Hospital, Endokrinologijas nodala
🇱🇻Riga, Latvia
KRH Klinikum Siloah
🇩🇪Hannover, Germany
Instituto de Pesquisa Clinica em Campinas
🇧🇷Campinas, Sao Paulo, Brazil
MAC Research
🇬🇧Barnsley, United Kingdom
Centro Cardiovascular Colombiano Clínica Santa María
🇨🇴Medellin, Antioquia, Colombia
Centro Cardiovascular y de Diabetes
🇨🇴Barranquilla, Atlantico, Colombia
Gastroenheden, Hvidovre hospital
🇩🇰Hvidovre, Copenhagen, Denmark
Centre Hospitalier de l'Universite de Montreal - CHUM
🇨🇦Montreal, Quebec, Canada
Saint-Petersburg City Pokrovskaya Hospital
🇷🇺St-Petersburg, Leningrad Region, Russian Federation
Studienzentrum Schwittay
🇩🇪Böhlen, Saxony, Germany
Synexus Magyarország kft. Gyula DRS
🇭🇺Gyula, Hungary
Digestive Diseases Centre GASTRO
🇱🇻Riga, Latvia
Recherche GCP Research
🇨🇦Montreal, Quebec, Canada
Klinische Forschung Dresden GmbH
🇩🇪Dresden, Saxony, Germany
Central Alberta Research Centre
🇨🇦Red Deer, Canada
Strázsahegy Gyógyszertár Medicina
🇭🇺Budapest, Hungary
Israelitisches Krankenhaus
🇩🇪Hamburg, Germany
BKS Research Kft Synexus AS
🇭🇺Hatvan, Heves, Hungary
Hetenyi Geza Hospital
🇭🇺Szolnok, Jász-Nagykun-Szolnok, Hungary
Polana-D
🇱🇻Daugavpils, Latvia
Centro de Investigacion Cardiometabolica de Aguascalientes SA de CV
🇲🇽Aguascalientes, Mexico
Biomedical Research Centre
🇬🇧Nottingham, United Kingdom
Synexus Merseyside Dedicated Research Centre
🇬🇧Liverpool, United Kingdom
Centro de Pesquisa Clinica do Brasil
🇧🇷Brasilia, Distrito Federal, Brazil
Synexus Clinical Research US, Inc.
🇺🇸San Antonio, Texas, United States
Optimal Research California
🇺🇸San Diego, California, United States
Synexus Clinical Research US - Cincinnati
🇺🇸Cincinnati, Ohio, United States
Pinnacle Clinical Research
🇺🇸San Antonio, Texas, United States
Digestive & Liver Disease Center of San Antonio, PLLC
🇺🇸San Antonio, Texas, United States
Núcleo de Pesquisa Clínica do Rio Grande do Sul
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Kansas Medical Clinic
🇺🇸Topeka, Kansas, United States
WestGlen Gastrointestinal Consultants
🇺🇸Shawnee Mission, Kansas, United States
Via Christi Clinic, PA
🇺🇸Wichita, Kansas, United States
Health Science Research Center
🇺🇸Pratt, Kansas, United States
Professional Research Network of Kansas, LLC
🇺🇸Wichita, Kansas, United States
Centennial Health-Synexus
🇺🇸Oklahoma City, Oklahoma, United States
Endocrinology, Aalborg University Hospital
🇩🇰Aalborg, Denmark
Center for Clinical Metabolic Research
🇩🇰Hellerup, Denmark
Sunnybrook Health Science Centre
🇨🇦Toronto, Ontario, Canada
Toronto Liver Centre
🇨🇦Toronto, Ontario, Canada
Synexus Clinical Research US - Simon Williamson Clinic
🇺🇸Birmingham, Alabama, United States
Heartland Clinical Research, Inc
🇺🇸Omaha, Nebraska, United States
Mid Essex Hospital Services NHS Trust Broomfield Hospital
🇬🇧Chelmsford, United Kingdom
Instituto de Pesquisa ClÍnica e Medicina AvanCada Ltda
🇧🇷SÃo Paulo, Brazil
CIDIM - Centro Integral de Diagnóstico por Imágenes Marchegian
🇦🇷Córdoba, Argentina
Palmetto Research, LLC
🇺🇸Hialeah, Florida, United States
North Alabama Research Center, LLC
🇺🇸Athens, Alabama, United States
Tibor Rubin VA Medical Center
🇺🇸Long Beach, California, United States
Unity Health - Searcy Medical Center
🇺🇸Searcy, Arkansas, United States
G & L Research, LLC
🇺🇸Foley, Alabama, United States
Applied Research Center of Arkansas
🇺🇸Little Rock, Arkansas, United States
GW Research Inc.
🇺🇸Chula Vista, California, United States
Stanford Hospital, Digestive Health Clinic
🇺🇸Palo Alto, California, United States
Syrentis Clinical Research
🇺🇸Santa Ana, California, United States
ALL Medical Research LLC
🇺🇸Cooper City, Florida, United States
New Hope Research Development
🇺🇸Whittier, California, United States
Gastroenterology Group of Naples
🇺🇸Naples, Florida, United States
North Shore University Health System
🇺🇸Evanston, Illinois, United States
American Research, LLC
🇺🇸Jeffersonville, Indiana, United States
Clinical Trials of America, Inc.
🇺🇸West Monroe, Louisiana, United States
Capital Diabetes and Endocrine Associates
🇺🇸Camp Springs, Maryland, United States
Meritus Center for Clinical Research
🇺🇸Hagerstown, Maryland, United States
Clinical Research Institute of Michigan
🇺🇸Chesterfield, Michigan, United States
Commonwealth Clinical Studies, PLLC.
🇺🇸Brockton, Massachusetts, United States
Aa Mrc Llc
🇺🇸Flint, Michigan, United States
Synexus Clinical Research US, Inc
🇺🇸Cincinnati, Ohio, United States
Carolina Digestive Health Associates, PA
🇺🇸Davidson, North Carolina, United States
USMA Clinical Research, LLC
🇺🇸Elizabeth, New Jersey, United States
Winthrop-University Hospital
🇺🇸Mineola, New York, United States
Kinston Medical Specialists, P.A.
🇺🇸Kinston, North Carolina, United States
PMG Research of Wilmington, LLC
🇺🇸Wilmington, North Carolina, United States
Diabetes & Endocrinology Associates of Stark County, Inc.
🇺🇸Canton, Ohio, United States
The MetroHealth System MHS
🇺🇸Cleveland, Ohio, United States
CIC America Clinical Inquest Center Ltd.
🇺🇸Dayton, Ohio, United States
Allegheny Endocrinology Associates
🇺🇸Pittsburgh, Pennsylvania, United States
Options Health Research, LLC
🇺🇸Tulsa, Oklahoma, United States
Preferred Primary Care Physicians
🇺🇸Uniontown, Pennsylvania, United States
Hometown Urgent Care and Research
🇺🇸Dayton, Ohio, United States
Care Access Research
🇺🇸Warwick, Rhode Island, United States
East Tennessee Research Institute
🇺🇸Johnson City, Tennessee, United States
Health Concepts
🇺🇸Rapid City, South Dakota, United States
Gastro One
🇺🇸Germantown, Tennessee, United States
ClinRx Research, LLC
🇺🇸Carrollton, Texas, United States
Clinsearch
🇺🇸Chattanooga, Tennessee, United States
Biopharma Informatic Inc., Research Center
🇺🇸Houston, Texas, United States
Sante Clinical Research
🇺🇸Kerrville, Texas, United States
Dwayne O. Williams MD
🇺🇸Sugar Land, Texas, United States
Blue Ridge Medical Research
🇺🇸Lynchburg, Virginia, United States
Washington Gastroenterology PLLC
🇺🇸Tacoma, Washington, United States
Instituto de Investigaciones Clinicas de Rosario
🇦🇷Rosario, Santa Fe, Argentina
CIPREC
🇦🇷Ciudad Autonoma de Buenos Aires, Argentina
Centro Universitario de Investigacion en Farmacologia Clinic
🇦🇷Corrientes, Argentina
Hospital Universitario Joao de Barros Barreto
🇧🇷Belem, Para, Brazil
Scentryphar Pesquisa Clinica Ltda
🇧🇷Campinas, Sao Paulo, Brazil
Toronto Digestive Disease Associates
🇨🇦Vaughan, Ontario, Canada
Eastern Health
🇨🇦St. John's, Newfoundland and Labrador, Canada
Rodrigo Botero S.A.S.
🇨🇴Medellin, Antioquia, Colombia
Fundacion Bios
🇨🇴Barranquilla, Atlantico, Colombia
Klinische Forschung Karlsruhe GmbH
🇩🇪Karlsruhe, Baden-SWürttemberg, Germany
Zala Megyei Szent Rafael Korhaz
🇭🇺Zalaegerszeg, Zala, Hungary
SYNEXUS Magyarorszag Kft Debrecen A.S.
🇭🇺Debrecen, Hungary
Synexus Budapest DRS
🇭🇺Budapest, Hungary
Markhot Ferenc Oktatokorhaz es Rendelointezet
🇭🇺Eger, Heves, Hungary
Centro Especializado en Diabetes, Obesidad y Prevencion de E - Endocrinology
🇲🇽Mexico, Distrito Federal, Mexico
Unidad de Investigacion Clinica Cardiometabolica de Occidente
🇲🇽Guadalajara, Jalisco, Mexico
Centro de Atención e Investigación en Factores de Riesgo Car
🇲🇽Mexico, Distrito Federal, Mexico
Consultorio Medico
🇲🇽Guadalajara, Jalisco, Mexico
GUZ Saratov City Clinical Hospital 9
🇷🇺Saratov, Saratov Region, Russian Federation
Scientific Institute of Clinical and Experimental Lymphology
🇷🇺Novosibirsk, Novosibirsk Oblast, Russian Federation
Nizhegorodsky Regional Clinical Hospital named after N. A. Semashko
🇷🇺Nizhny Novgorod, Volga, Russian Federation
Moscow Regional Research Clinical Institute named by MF Vladimirski
🇷🇺Moscow, Russian Federation
Kazan State Medical University
🇷🇺Kazan, Russian Federation
FSBI National medical endocrinology research centre
🇷🇺Moscow, Russian Federation
Rostov on Don
🇷🇺Rostov on Don, Russian Federation
Rostov State Medical University
🇷🇺Rostov-on-Don, Russian Federation
North-Western State Medical University named after I. I. Mechnikov
🇷🇺Saint-Petersburg, Russian Federation
Synexus Stanza Clinical Research Centre
🇿🇦Pretoria, Gauteng, South Africa
Saratov City Clinical Hospital 12
🇷🇺Saratov, Russian Federation
FARMOVS
🇿🇦Bloemfontein, Free State, South Africa
Watermeyer Clinical Research Site
🇿🇦Silverton, Gauteng, South Africa
TREAD Research
🇿🇦Cape Town, South Africa
Synexus Helderberg Clinical Research Centre
🇿🇦Cape Town, Western Cape, South Africa
MAC Clinical Research Manchester
🇬🇧Manchester, Greater Manchester, United Kingdom
Synexus Lancashire Dedicated Research Centre
🇬🇧Chorley, Lancashire, United Kingdom
Royal Oldham Hospital
🇬🇧Oldham, Lancashire, United Kingdom
MAC Research, Exchange House
🇬🇧Cannock, Staffordshire, United Kingdom
University Hospitals of North Midlands
🇬🇧Stoke on Trent, Staffordshire, United Kingdom
MAC Clinical Research, Monarch House
🇬🇧Leeds, West Yorkshire, United Kingdom
Synexus Wales Clinical Research Centre
🇬🇧Cardiff, United Kingdom
Royal Wolverhampton NHS Trust
🇬🇧Wolverhampton, West Midlands, United Kingdom
MAC Clinical Research
🇬🇧Liverpool, United Kingdom
Western General Hospital
🇬🇧Edinburgh, United Kingdom
Wingate Institute of Neurogastroenterology and Barts Health Trust and the Royal London Hospital
🇬🇧London, United Kingdom
MAC Clinical Research, GAC House
🇬🇧Manchester, United Kingdom
Royal Victoria Infirmary: Clinical Research Facility
🇬🇧Newcastle upon Tyne, United Kingdom
Synexus Manchester Clinical Research Centre
🇬🇧Manchester, United Kingdom
Synexus Hexham Dedicated Research Centre
🇬🇧Stockton-on-Tees, United Kingdom
Synexus North Tees Clinical Research Centre
🇬🇧Stockton-on-Tees, United Kingdom
Cleveland Clinic Florida - Weston
🇺🇸Weston, Florida, United States
Vida Clinical Trials
🇺🇸Homestead, Florida, United States
Clinical Research of West Florida
🇺🇸Clearwater, Florida, United States
iResearch Atlanta LLC
🇺🇸Decatur, Georgia, United States
Rocky Mountain Diabetes and Osteoporosis Center, PA
🇺🇸Idaho Falls, Idaho, United States
Washington University in St. Louis
🇺🇸Saint Louis, Missouri, United States
Guthrie Clinical Research
🇺🇸Sayre, Pennsylvania, United States
Wits Clinical Research
🇿🇦Johannesburg, Gauteng, South Africa
Diabetes and Endocrinology Consultants, PC
🇺🇸Morehead City, North Carolina, United States
University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States
Frontier Clinical Research, LLC
🇺🇸Smithfield, Pennsylvania, United States
Texas Clinical Research Institute, LLC
🇺🇸Arlington, Texas, United States
PMG Research of Winston-Salem, LLC
🇺🇸Winston-Salem, North Carolina, United States
Clinical Trials of South Carolina
🇺🇸Charleston, South Carolina, United States
VA Medical Center McGuire VAMC
🇺🇸Richmond, Virginia, United States
Lovelace Scientific Resources, Inc.
🇺🇸Albuquerque, New Mexico, United States
Alberta Diabetes Institute
🇨🇦Edmonton, Alberta, Canada
Trialspark - Sood
🇺🇸Bowie, Maryland, United States
Metropolitan Gastroenterology Group PC, Chevy Chase Clinical Research
🇺🇸Chevy Chase, Maryland, United States
TriWest Research Associates
🇺🇸Poway, California, United States
Tandem Clinical Research
🇺🇸Marrero, Louisiana, United States
Gwinnett Research Institute, LLC
🇺🇸Buford, Georgia, United States
Clinical Trials of SWLA, LLC
🇺🇸Lake Charles, Louisiana, United States
Woodholme Gastroenterology Associates, P.A.
🇺🇸Glen Burnie, Maryland, United States
Instituto de Hematologia y Medicina Clinica Dr. Ruben Davoli
🇦🇷Rosario, Santa Fe, Argentina
IPS Centro Medico Julian Coronel S.A
🇨🇴Cali, Valle Del Cauca, Colombia
Centro Medico Imbanaco de Cali S.A.
🇨🇴Cali, Valle Del Cauca, Colombia