Novel MRI Techniques in the Evaluation of Pulmonary Vascular Disease

Phase 1

Completed

• Conditions: Pulmonary Hypertension

• Registration Number: NCT02026531
• Lead Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust

Brief Summary

The diagnosis of a patient with pulmonary hypertension (PH) requires many investigations. At present cardiac catheterisation is the cornerstone investigation in these patients where it is used to establish disease severity and estimate prognosis. It is an invasive procedure which is expensive and not without risk to the patient. Despite the multitude of tests performed, identifying those patients with PH who have a poor diagnosis can be difficult. The aim of this study is to improve the assessment of patients with PH using novel magnetic resonance techniques.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-11
• Study First Submitted: 2012-06-08
• Study First Submitted QC: 2014-01-02
• Study First Posted: 2014-01-03
• Status Verified: 2015-09
• Primary Completion: 2015-09
• Study Completion: 2015-09
• Last Update Submitted: 2015-09-28
• Last Update Posted: 2015-09-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 9

Inclusion Criteria

• All cases referred to the clinic for assessment for possible pulmonary hypertension.

Exclusion Criteria

• patients with a cardiac pacemaker or retained temporary pacing wire
• patients with aneurysm clip
• non MRI compatible heart valve prosthesis
• intra orbital metalic foreign body
• pregnancy
• metal prosthesis/spinal rods
• retained shrapnel
• cochlear implants/bladder stimulator

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
pulmonary artery diameter (mm)	up to 3 months	Three-dimensional MRI imaging will be used to acquire cardiac dimensions and anatomical ventilation distribution as well as regional partial pressures of oxygen in the lungs.

Trial Locations

Locations (1)

Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital; 🇬🇧 Sheffield, South Yorkshire, United Kingdom