Novel MRI Techniques in the Evaluation of Pulmonary Vascular Disease
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Pulmonary Hypertension
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
- Enrollment
- 9
- Locations
- 1
- Primary Endpoint
- pulmonary artery diameter (mm)
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The diagnosis of a patient with pulmonary hypertension (PH) requires many investigations. At present cardiac catheterisation is the cornerstone investigation in these patients where it is used to establish disease severity and estimate prognosis. It is an invasive procedure which is expensive and not without risk to the patient. Despite the multitude of tests performed, identifying those patients with PH who have a poor diagnosis can be difficult. The aim of this study is to improve the assessment of patients with PH using novel magnetic resonance techniques.
Investigators
Eligibility Criteria
Inclusion Criteria
- •All cases referred to the clinic for assessment for possible pulmonary hypertension.
Exclusion Criteria
- •patients with a cardiac pacemaker or retained temporary pacing wire
- •patients with aneurysm clip
- •non MRI compatible heart valve prosthesis
- •intra orbital metalic foreign body
- •pregnancy
- •metal prosthesis/spinal rods
- •retained shrapnel
- •cochlear implants/bladder stimulator
Outcomes
Primary Outcomes
pulmonary artery diameter (mm)
Time Frame: up to 3 months
Three-dimensional MRI imaging will be used to acquire cardiac dimensions and anatomical ventilation distribution as well as regional partial pressures of oxygen in the lungs.