Treatment of tachycardia-bradycardia syndrome using radiofrequency catheter ablation of paroxysmal atrial fibrillation versus permanent pacemaker implantation: prospective, randomized trial

Not Applicable

Recruiting

Conditions: Diseases of the circulatory system

Registration Number: KCT0000155

Lead Sponsor: Asan Medical Center

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 88

Inclusion Criteria

1. Documented prolonged sinus pauses on termination of AF ranging from 3 to 9 seconds
2. Symptoms of syncope or presyncope
3. Informed consent

Exclusion Criteria

1. Left ventricular ejection fraction < 40%
2. prior history of ablation of atrial fibrillation
3. thrombi in Left atrium or Left atrial appendage
4. New York Heart Association class III or IV
5. prior acute myocardial infarction or coronary artery bypass grafting within 6 months
6. prior percutaneous coronary intervention within 1 year
7. Severe valvular disease
8. Life expectancy of less than one year
9. Contraindication of anticoagulants
10. Pregnant women or women planning pregnancy(The urine hCG test is usually performed in women of reproductive age)

Study & Design

Study Type: Interventional Study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
all-cause hospitalization and syncope

Secondary Outcome Measures

Name	Time	Method
all-cause death;atrial fibrillation burden by 24-hour ambulatory ECG monitoring;Minimum heart rate, Maximum pause, number of sinus pause > 3 seconds by 24-hour ambulatory ECG monitoring;LA size on transthoracic echocardiography ;treadmil test