A study to know the efficacy of dexmeditomidine as an anti shivering agent after spinal anaesthesia.

Not yet recruiting

• Conditions: Post Spinal Shivering; Medical and Surgical,

• Registration Number: CTRI/2022/02/039937
• Lead Sponsor: Dr Reema Rajshekhar Wali

Brief Summary

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|Spinal anaesthesia is a procedure which is ubiquitous in every healthcare setup. From the day it was described by August Bier in 1898, this technique has undergone many modifications. The management of its complications have  undergone many changes to make it more safer and acceptable. One of the complications which still haunts the anaesthesiologists and thus needs further modifications in its management is shivering.

Shivering is a protective phenomenon which occurs when there is a drop in the core body temperature. As patients plunge into anaesthesia, shivering is always bound to happen and its avoidance is of prime importance.

The main control of temperature in human body is through the hypothalamus, which regulates body temperature between 36.50 to 37.50 Celsius and this is known as inter threshold range1. It is important to maintain this range of temperature for optimal metabolic and physiological functioning and any variations, will lead to derangement of these functions. During any form of anaesthesia there is an imbalance in the body’s ability to generate heat as compared to heat loss. In general anaesthesia use of inhalational anaesthetics, inhibition of autonomic system and behavioral responses makes patient suffer from hypothermia, whereas in spinal anaesthesia there is shift of heat to periphery from core2. Drugs used in treatment of shivering are:Tramadol,Pethidine,nefopam, physostigmine, ketamine, ondansetron, and granisetron3.

Many trials of dexmedetomidine in prevention of shivering after general anaesthesia have been done, with only few studies of dexmedetomidine in spinal anaesthesia. Hence the present study will be undertaken.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-01-02
• Study Start: 2022-07-02

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• 1.ASA physical status I and II.
• 2.Age between 18 to 65 years.
• 3.Patient undergoing surgeries under spinal anaesthesia.

Exclusion Criteria

1.Allergic to the study drugs-bupivacaine and dexmedetomidine 2.A Pre-Operative baseline temperature of more than 37.5 degreeCelsius 3.Patients on long standing opioids 4.Patients suffering from thyroid disorders 5.Patient undergoing surgeries like TURP, where irrigation fluids are used.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1.To study the efficacy of dexmedetomidine in prevention of shivering in adult patients undergoing surgeries under spinal anaesthesia	10 minutes from Time of Spinal Injection to 180 minutes

Secondary Outcome Measures

Name	Time	Method
To know the side effects of dexmedetomidine	From time of Spinal Injection to 180 minutes

Trial Locations

Locations (1)

Basaveshwar Teaching and General Hospital; 🇮🇳 Gulbarga, KARNATAKA, India

Basaveshwar Teaching and General Hospital

🇮🇳Gulbarga, KARNATAKA, India

Dr Reema Rajshekhar Wali

Principal investigator

8867850200

reemawali2@gmail.com