Clinical Study of Relationship Between Granulocyte Activation, HDAC2 and Severe Asthma

• Conditions: Asthma
• Interventions: Other: severe asthma group

• Registration Number: NCT02881502
• Lead Sponsor: Xijing Hospital

Brief Summary

Program： Clinical Study of Relationship Between Granulocyte Activation, HDAC2 and Severe Asthma Aim：The early prediction of severe asthma, early intervention on the disease, reduce the family and the national finance.

design:This study is a single center randomized controlled trial designed by the Department of respiratory medicine, Xijing Hospital, as the main research unit.Compare the case group(severe asthma group and mild-and-moderate asthma group) and control group(healthy control group) by detecting the activity of MPO、NE、MMP-9 and ECP in the peripheral blood and the activity of HDAC2 in PBMCs of patients.

case:60

Case selection:

Inclusion criteria: age 18-75 years old; diagnosis of asthma was clear; informed consent was signed.

Exclusion criteria: poor compliance; cognitive ability is low; psychiatric disorders need to be combined with psychotropic medication.

Detailed Description

Application of SPSS 19 statistical software. Measurement data were expressed as mean ± standard deviation.

First the data is normality tested and homogeneity of variance tested, according to the measurement data of normal distribution by SNK single factor analysis of variance; does not conform to the normal distribution of measurement data, using the Kruskal Wallis non parametric test. P \< 0.05 for the difference was statistically significant.

Study Timeline

• Study Start: 2016-06
• Study First Submitted: 2016-07-15
• Status Verified: 2016-08
• Study First Submitted QC: 2016-08-23
• Last Update Submitted: 2016-08-23
• Study First Posted: 2016-08-29
• Last Update Posted: 2016-08-29
• Primary Completion: 2017-07
• Study Completion: 2017-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
severe asthma group	severe asthma group	Outpatient patients with severe asthma diagnosis, in accordance with the inclusion criteria and exclusion criteria.

Primary Outcome Measures

Name	Time	Method
Evidence of clinically definite severe asthma confirmed by the plasma concentration of blood related indexes(MPO、MMP-9、NE、ECP、HDAC2)	one year	Compare the difference was not statistically significant of the different groups by testing the concentration of blood related indicators of subjects

Trial Locations

Locations (1)

XijingH; 🇨🇳 Xian, Shanxi, China