Effects of Calcium and Phytate on Zinc Absorption

Not Applicable

Completed

• Conditions: Dietary Zinc Absorption
• Interventions: Dietary Supplement: Moderate Calcium, Low phytate Diet; Dietary Supplement: Moderate Calcium, High Phytate Diet; Dietary Supplement: High Calcium, Low Phytate Diet; Dietary Supplement: High Calcium, High Phytate Diet

• Registration Number: NCT00754390
• Lead Sponsor: USDA Grand Forks Human Nutrition Research Center

Brief Summary

This study is determine the effects of dietary calcium and phytate on zinc absorption.

Detailed Description

Zinc absorption is tested from 2 days of consuming each of four diets with zinc-65 isotope, followed by retention monitoring in a whole body scintillation counter for 4 weeks. All four 4 experimental diets are tested with each subject, in randomized order, for a total of 16 weeks.

Study Timeline

• Study Start: 2005-11
• Primary Completion: 2006-05
• Study Completion: 2006-05
• Study First Submitted: 2008-09-16
• Study First Submitted QC: 2008-09-17
• Study First Posted: 2008-09-18
• Results First Submitted: 2008-12-17
• Results First Submitted QC: 2009-04-15
• Results First Posted: 2009-06-08
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-24
• Last Update Posted: 2018-07-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 17

Inclusion Criteria

• Average weight for height

Exclusion Criteria

• Medications other than birth control pills or hormone replacement therapy,
• Pregnancy within last 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Overall Study	Moderate Calcium, High Phytate Diet	Participants consumed 4 experimental diets for 4 weeks each in randomized order
Overall Study	High Calcium, Low Phytate Diet	Participants consumed 4 experimental diets for 4 weeks each in randomized order
Overall Study	Moderate Calcium, Low phytate Diet	Participants consumed 4 experimental diets for 4 weeks each in randomized order
Overall Study	High Calcium, High Phytate Diet	Participants consumed 4 experimental diets for 4 weeks each in randomized order

Primary Outcome Measures

Name	Time	Method
Zinc Absorption	16 weeks	Retention of Zinc-65 was monitored for 28 days by whole body scintillation counting. The percentage of Zinc-65 absorbed was estimated from the y-intercept of the linear portion of a semilogarithmic retention plot of percent Zinc-65 retained versus time

Trial Locations

Locations (1)

United States Department of Agriculture Grand Forks Human Nutrition Research Center; 🇺🇸 Grand Forks, North Dakota, United States