Comparison of general anaesthesia using Desflurane at low flow (1 L/min)and medium flow rates (2L/min)

Active, not recruiting

• Conditions: American Society of Anesthesiologists status I and II

• Registration Number: CTRI/2017/01/007699
• Lead Sponsor: PGIMER DR RAM MANOHAR LOHIA HOSPITAL

Brief Summary

Low flow anaesthesia is defined as any technique where the fresh gas flow is less than the alveolar ventilation.Low solubility inhalational anaesthetic agents and high precision monitoring techniques have enabled modern day anaesthesiologists to employ low flow anaesthesia on a daily basis.Therefore we planned to conduct this study to determine the efficacy of low flow Desflurane anaesthesia by comparing the effects of low flow Desflurane anaesthesia (1 L/min) with those of medium flow anaesthesia (2L/min) on Oxygen and Desflurane concentration, Desflurane consumption and recovery profile.



After obtaining approval from the institutional ethics committee, a randomised controlled study with two groups of patients(30 in each) of Low flow (1L/min) and Medium flow(2L/min) anaesthesia was conducted, comparing inspired and expired Oxygen and Desflurane concentrations, recovery profile of patients and Desflurane consumption between the two.



The parameters monitored in both the groups were heart rate, blood pressure, mean arterial pressure, pulse oximetry,nasopharyngealtemperature,capnography,inspired and expired concentrations of Oxygen, inspired and expiredconcentrationsof Nitrous oxide, inspiredand expired concentrations of Desflurane,minimum alveolar concentration, bispectral index,arterial blood gas analysis. Modified Aldrete score was used for assessing recovery profile and total Desflurane consumption was calculated.



Based on the values of the above mentioned parameters the statistical analysis shall be formulated using the student’s t test and a p value of <0.05 will be considered statistically significant.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01-03
• Last Update Posted: 2016-06-18

Recruitment & Eligibility

• Status: Closed to Recruitment of Participants
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• 1.ASA status I and II.
• 2.Age group 18 to 60 years.
• 3.Posted for elective surgery under general anaesthesia.
• 4.Duration of the anaesthesia 90 to 180 minutes approximately.

Exclusion Criteria

• 1.Laparoscopic surgery.
• 2.Pregnancy.
• 3.Obesity with BMI > 30.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the inspired and expired oxygen and desflurane concentrations in low flow(1 L/min) with medium flow (2 L/min) desflurane anaesthesia	Baseline(pre operative) | 10 mins | 20 mins | 30 mins | 60 mins | 90 mins | 120 mins | 150 mins | 180 mins | ABG- Baseline | 20 mins after switching to low flow | 20 mins before reversal

Secondary Outcome Measures

Name	Time	Method
To compare the recovery profile and desflurane consumption of the patients of low flow (1 L/min) with medium flow (2 L/min) desflurane anaesthesia	MODIFIED ALDRETE SCORE -

Trial Locations

Locations (1)

Dr.Ram Manohar Lohia Hospital; 🇮🇳 Central, DELHI, India

Dr.Ram Manohar Lohia Hospital

🇮🇳Central, DELHI, India

Dr Anjali Kundu

Principal investigator

7042068660

anjali.kundu@gmail.com