Low-Flow Anesthesia and Open-Heart Surgery

Not yet recruiting

• Conditions: Low-flow Anesthesia; Hemodynamics; Open-heart Surgery

• Registration Number: NCT07040735
• Lead Sponsor: Çağrı Özdemir

Brief Summary

Low-flow anesthesia (LFA) is a technique in which at least 50% of the exhaled air, after carbon dioxide absorption, is mixed with a certain amount of fresh gas and returned to the patient during the next inspiration. In 1974, R. Virtue defined minimal flow anesthesia (MFA) as 0.5 L/min. In 1984, Baker and Simionescu classified LFA as 0.5-1 L/min and MFA as 0.25-0.5 L/min. The aim of this study is to investigate whether there are hemodynamic differences between open-heart surgery cases performed with LFA at different fresh gas flow rates.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-06
• Study First Submitted: 2025-06-06
• Study First Submitted QC: 2025-06-18
• Study First Posted: 2025-06-27
• Last Update Submitted: 2025-06-30
• Study Start: 2025-07-01
• Last Update Posted: 2025-07-03
• Primary Completion: 2026-01-01
• Study Completion: 2026-02-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

-≥18 years and scheduled for open-heart surgery patients

-ASA I-II-III-IV physical class

Exclusion Criteria

• Emergency cases
• Patients under 18 years of age
• Patients who have had open heart surgery before
• Patients for whom the use of inhaled anesthetic agents is contraindicated
• Patients who do not sign a voluntary consent form

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
physiological parameter ; heart rate	Intraoperatively	Heart rate will be recorded every 10 minutes, expressed as beats per minute, starting before induction and including the sternotomy and pericardiotomy periods.
physiological parameter; systolic/diastolic blood pressure	Intraoperatively	Systolic and diastolic blood pressure will be recorded every 10 minutes in mmHg, starting before induction and including the sternotomy and pericardiotomy periods.
physiological parameter; SpO2	Intraoperatively	SpO2 will be recorded as a percentage every 10 minutes, starting before induction and including the sternotomy and pericardiotomy periods.
Monitoring parameter; Bispectral Index (BIS)	Intraoperatively	The BIS value will be recorded numerically every 10 minutes, starting from before induction and including the sternotomy and pericardiotomy periods.
Monitoring parameter; Minimum alveolar concentration (MAC)	Intraoperatively	The MAC value will be recorded numerically every 10 minutes, starting from before induction and including the sternotomy and pericardiotomy periods.

Secondary Outcome Measures

Name	Time	Method
Preoperative data; ASA classification	24 hours before surgery	During the preoperative period, the patient's ASA classification will be recorded as I, II, III, IV.
Preoperative data	24 hours before surgery	In the preoperative period, the degree of valve dysfunction (such as I.degree TY, II.degree MY) of the patients will be recorded.
Preoperaitive data	24 hours before surgery	In the preoperative period, the patient's ejection fraction will be recorded as a percentage.

Trial Locations

Locations (1)

Gazi University Faculty of Medicine; 🇹🇷 Ankara, Turkey