The Effect of Low-Flow Anesthesia on Hemodynamics in Open-Heart Surgery
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 80
- Locations
- 2
- Primary Endpoint
- physiological parameter ; heart rate
Study Overview
Brief Summary
Low-flow anesthesia (LFA) is a technique in which at least 50% of the exhaled air, after carbon dioxide absorption, is mixed with a certain amount of fresh gas and returned to the patient during the next inspiration. In 1974, R. Virtue defined minimal flow anesthesia (MFA) as 0.5 L/min. In 1984, Baker and Simionescu classified LFA as 0.5-1 L/min and MFA as 0.25-0.5 L/min. The aim of this study is to investigate whether there are hemodynamic differences between open-heart surgery cases performed with LFA at different fresh gas flow rates.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •≥18 years and scheduled for open-heart surgery patients
- •ASA I-II-III-IV physical class
Exclusion Criteria
- •Emergency cases
- •Patients under 18 years of age
- •Patients who have had open heart surgery before
- •Patients for whom the use of inhaled anesthetic agents is contraindicated
- •Patients who do not sign a voluntary consent form
Outcomes
Primary Outcomes
physiological parameter ; heart rate
Time Frame: Intraoperatively
Heart rate will be recorded every 10 minutes, expressed as beats per minute, starting before induction and including the sternotomy and pericardiotomy periods.
physiological parameter; systolic/diastolic blood pressure
Time Frame: Intraoperatively
Systolic and diastolic blood pressure will be recorded every 10 minutes in mmHg, starting before induction and including the sternotomy and pericardiotomy periods.
physiological parameter; SpO2
Time Frame: Intraoperatively
SpO2 will be recorded as a percentage every 10 minutes, starting before induction and including the sternotomy and pericardiotomy periods.
Monitoring parameter; Bispectral Index (BIS)
Time Frame: Intraoperatively
The BIS value will be recorded numerically every 10 minutes, starting from before induction and including the sternotomy and pericardiotomy periods.
Monitoring parameter; Minimum alveolar concentration (MAC)
Time Frame: Intraoperatively
The MAC value will be recorded numerically every 10 minutes, starting from before induction and including the sternotomy and pericardiotomy periods.
Secondary Outcomes
- Preoperative data; ASA classification(24 hours before surgery)
- Preoperative data(24 hours before surgery)
- Preoperaitive data(24 hours before surgery)
- Preoperative data(24 hours before surgery)
Investigators
Çağrı Özdemir
asst. prof.
Gazi University