Evaluating transcatheter arterial embolisation for improvement of pain in osteoarthritis (OA) of the knee - a pilot study

Barwon Medical Imaging0 个研究点目标入组 10 人开始时间: 2016年6月14日最近更新: 2023年4月10日

适应症

试验速览

暂无简介。

•1. People aged 18 to 75 years
•2. Grade 1 or 2 knee OA (obtained via baseline imaging (X-Ray) as per Kellgren-Lawrence Grading Scale)
•3. Moderate to severe knee pain
•4. Pain resistant to conservative treatment
•a. Conservative treatment includes medication (e.g. paracetamol, anti-inflammatories), or intra-articular injections, or physiotherapy or exercise, or weight loss.
•5. Participants must be willing, able and mentally competent to provide informed consent (able to read and understand the Patient Information and Consent Form).

•1. Local infection
•2. Active malignancy
•3. Rheumatoid Arthritis or Seronegative Arthropathies
•4. Prior Ipsilateral Knee Surgery
•5. Kellgren-Lawrence Grade 3 and above
•6. Current pregnancy
•a. If participant is unsure of their current pregnancy status clarification from their GP including arranging a pregnancy test and following up the result can be obtained
•7. Known history of allergy to contrast media
•8. Reduced kidney function or failure (chronic or acute)
•a. Acute kidney injury (Defined by KDIGO: Increase in a participant’s serum creatinine level by >0.3mg/dL (>26.5 micromol/L) within 48 hours OR Increase in a participants serum creatinine by >1.5x their baseline OR Oliguria (urinary output <0.5mL/kg/hr) for 6 hours
•9. Weight greater than 200kg
•10. Barwon Medical Imaging Protocols:
•a.Platelets < 100 x 109/L
•b. INR > 1.5
•c. Estimated GFR < 30ml/min.1.73m2
•11. Approved for knee joint replacement surgery
•12. Moderate to severe pain in other lower limb joints

发起方

Barwon Medical Imaging