Impact of Resistant Starch Type-3 on Glucose Metabolism and Appetite in Healthy Adult Males
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- Changes in fasting and postprandial blood glucose concentrations (n=8)
研究概览
简要总结
Resistant starch (RS) is considered to have many of the same health benefits as dietary fiber. The aim of this study was to examine the effects of RS3 on postprandial glycemic and insulinemic responses and appetite.
Healthy males (aged 18-35 years) participated in this study. Subjects were provided meals in the laboratory after overnight fasting on two separate occasions, at least 1 week apart. On each laboratory visit, subjects were given either a control meal (COM) or an RS3 meal (RSM). Both meals during the two visits consisted of vegetarian pasta and were matched for energy intake, composition, ingredients, and amount, but were prepared in different ways. The COM was hot, freshly cooked pasta, while the RSM was re-heated pasta that had been cooked the previous day and chilled overnight. Blood samples and subjective appetite ratings were collected at fasting and for a period of 3 h after meal consumption (i.e., 15-min intervals for glucose and 30-min intervals for insulin, ghrelin, and subjective appetite).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy males
- •Aged between 18 and 40 years
- •Normal weight (BMI 18.5-24.9 kg/m2)
- •No history of serious disease or currently taking any medications
- •Not dieting or seeking to lose weight.
排除标准
- •Allergy to gluten-containing products, lactose intolerance, or dairy allergy
- •Particular dislike to any of the foods provided during the study.
结局指标
主要结局
Changes in fasting and postprandial blood glucose concentrations (n=8)
时间窗: 3 hours
Fasting and postprandial blood glucose assessed with the use of a portable monitor (Accu-Chek) during laboratory visits (before and 3 hours following the meal consumption in the two visits).
次要结局
- Changes in of fasting and postprandial serum insulin concentrations (n=8)(3 hours)
- Changes in subjective appetite ratings (Visual Analogue Scale) (n=8)(3 hours)
- Changes in fasting and postprandial plasma ghrelin concentrations (n=8)(3 hours)
研究者
Maha Alhussain
Principal Investigator
King Saud University