Effect of Trikatu choorna in the management of Medo Dushti W.S.R to Primary Hyper Triglyceridemia An open lable clinical trial

The term dyslipidaemia denotes disorders of lipid metabolism Majority of the population is following inappropriate fatty diet regimen and sedentary lifestyle which may lead to a state of dyslipidaemia Dyslipidaemia denotes the state where there can be overproduction or decrease in production of lipoprotein The crude HTG prevalence rates were 29.6% in global population 36.9% in men and 23.8% in women The sex and age adjusted HTG prevalence rates were 27.0% in global population34.6% in men and 21.4% in women A fifth of the female adult population and more than a third of the male population had HTG The prevalence rates of various fasting dyslipidaemia in the first phase of ICMR INDIAN study restricted to urban and rural populations in 4 states in India was hypercholesterolemia in 13.9%, high triglycerides in 29.5% low HDL cholesterol in 72.3% and high LDL cholesterol in 11.8% 79%men and women had abnormalities in at least one of the lipid parameters Triglycerides are fatty acids and denotes the main lipid component of dietary fat They store unused calories and provide your body with energy  According to AMERICAN HEART HEALTH(AHA)factors affecting the triglyceride includes Diet Exercise level Diabetes  Inflammatory disease  Alcohol consumption  Obesity  Medications  Age  Sex  Pregnancy  The normal level of triglycerides in blood 150mg/dl (Acc National Cholesterol Education Program Adult Treatment Panel III) Normal <150 Borderline 150-199 High 200-499 Very high >500 Hypertriglyceridemia (HG) is an independent risk factor with more prevalence than hypercholesterolemia and its attributes to cardiovascular disease (CVD) and pancreatitis Hence it becomes imperative to search for new triglyceride (TG) lowering agents In Ayurveda  medodushti is pathological event which causes sthoulya which comes under Ashtanindita  The Ayurvedic description of Medodushtijanya Sign and  Symptoms bears a remarkable resemblance to the current texts explanation of dyslipidemia  As stated According to Ayurveda a diet high in Shleshma Vardhak Ahara Vihara and low in exercise lead to Agnidushti which in turn causes an excess of Sama Meda to form  As a result Medovriddhi  and  Medodushti  appears   Acharya Sushruta explained TRIKATU which consist of 3 drugs PIPALLI (PIPER LONGUM)  MARICH (PIPER NIGRUM) SHUNTHI (ZINGIBER OFFINCINALE) as kaphomedaghna  Sharangdhar explains trikatu as dipana shleshma MEDOGHNA6 kushta pinasnashanam which means drugs which do agni dipana and reduces excess of meda The drugs present in trikatu mainly has KATU RASA and USHNA VEERYA  Katu rasa will scrape the meda in the strotas and usna veerya will do pachan of the meda  Building certainty on simple formulation and minimal expenses with high compelling treatment is need of the time  Keeping this in view trikatu choorna capsule with compelling dose is considered for the ongoing review