To compare the effect of anesthesia with anaesthetic gas sevoflurane versus isoflurane on blood sugar levels in brain cancer surgeries

Phase 1

Not yet recruiting

Conditions: Medical and Surgical,

Registration Number: CTRI/2025/03/083071

Lead Sponsor: PGIMS Rohtak

Brief Summary: This study is a prospective double blind randomizedclinical trial. Aim of the study is to compare the c in non diabetic patientsundergoing intracranial mass excision surgery. The objective of the study is tosee the change in hourly blood sugar level trends from baseline, with the intraoperativeuse of inhalational agents; sevoflurane and isoflurane for maintainence.This study is a prospective double blind randomizedclinical trial. Aim of the study is to compare the c in non diabetic patientsundergoing intracranial mass excision surgery. The objective of the study is tosee the change in hourly blood sugar level trends from baseline, with the intraoperativeuse of inhalational agents; sevoflurane and isoflurane for maintainence.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 90

Inclusion Criteria

Patients of any sex, non diabetic, ASA status I & II and posted for intracranial mass excision surgery under general anesthesia.

Exclusion Criteria

The patients who are diabetic, have disorders of glucose metabolism, are pregnant and lactating , have renal, cardiovascular, pulmonary or hepatic disease, are chronic alcoholic, are taking insulin, oral hypoglycemic agents, antipsychotic drugs and beta adrenergic blocking drugs or are not willing to give consent.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To note the baseline blood glucose level (before induction) and then the hourly change in intraoperative glucose levels with the use of sevoflurane or isoflurane as a maintenance inhalational agent.	Before induction and every hour after induction till completion of surgery

Secondary Outcome Measures

Name	Time	Method
To note the baseline heart rate, saturation and mean arterial blood pressure and intraoperatively every 2 hour after induction.	Before induction and every two hour after induction till completion of surgery

Trial Locations

Locations (1): PGIMS Rohtak
🇮🇳
Rohtak, HARYANA, India
PGIMS Rohtak
🇮🇳Rohtak, HARYANA, India
Dr Nitu yadav
Principal investigator
8708642484
ynitu29@gmail.com