NCT03565302Unknown不适用
Gender-specific Role of the beta2-adrenergic Stimulation With Short- or Long-acting Selective Agonist in Relation to Muscle Remodelling, Function, Performance, and Anti-doping
Morten Hostrup, PhD1 个研究点 分布在 1 个国家目标入组 72 人开始时间: 2018年6月25日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- Proteome enrichment
研究概览
简要总结
The study aims to investigate gender-specific adaptations to beta2-adrenoceptor stimulation with selective short- and long-acting beta2-agonist with emphasis on skeletal muscle in relation to performance enhancing effects and anti-doping
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women, aged 18-45 years
- •VO2max >55 ml/kg/min for men and >50 ml/kg/min for women (± biologic and techinical variation of 5.6% (Katch et al. 1982)
- •Body Mass Index (BMI) < 26
排除标准
- •Chronic user of beta2-agonist or allergy towards study drugs
- •Serious adverse side effects of the used study drug
- •Chronic disease that by the project physician would affect any of the outcomes of the study
- •Chronic use of prescription medication (other than contraceptives for women)
- •Pregnancy
研究组 & 干预措施
Short acting beta2-agonist
Experimental
Subjects are treated with short-acting beta2-agonist terbutaline
干预措施: Terbutaline (Drug)
Control
Placebo Comparator
Subjects receive placebo treatment
干预措施: Placebo (Other)
Long acting beta2-agonist
Experimental
Subjects are treated with long-acting beta2-agonist formoterol
干预措施: Formoterol (Drug)
结局指标
主要结局
Proteome enrichment
时间窗: Baseline and 6 weeks
Change in enrichment (measured in muscle biopsies and assessed using GO annotations)
次要结局
- Body composition(Baseline, 2 weeks, 4 weeks and 6 weeks)
- Maximal oxygen consumption (VO2max)(Baseline, 2 weeks, 4 weeks and 6 weeks)
研究者
Morten Hostrup, PhD
Associate Professor
University of Copenhagen
研究点 (1)
Loading locations...
相似试验
Unknown
不适用
Physiologic Performance Response to SalbutamolHealthyNCT04615611University of Copenhagen20
尚未招募
2 期
Physiology of brown fat in humansObesityACTRN12611001198910HMRC70
已完成
不适用
Chronic Beta2-adrenergic Stimulation and Cardiac and Skeletal Muscle HypertrophyMuscle Hypertrophy in Healthy Young MenNCT02551276University of Copenhagen42
已完成
不适用
How Different Beta-2 Receptor Genotypes Affect an Asthmatic's Response to Regular Salmeterol TreatmentAsthmaNCT00595361Brigham and Women's Hospital30
已完成
不适用
Effects of Gender-Affirming Hormone Therapy Among Transgender WomenTransgender WomenHIV/AIDSCardiovascular DiseasesMetabolic DiseaseCoagulopathyNCT04128488Massachusetts General Hospital33