Multiparametric brain mapping study
Not Applicable
- Conditions
- Health Condition 1: C719- Malignant neoplasm of brain, unspecified
- Registration Number
- CTRI/2022/09/045769
- Lead Sponsor
- Tata Memorial Hospital TMC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Adults ( > 15 years)
2. Suspected glioma (radiological)
3. Planed for resection
4. Requiring intraoperative mapping (GA or awake)
Exclusion Criteria
1. Unresectable tumor where only biopsy is possible
2. Previous tumor-directed treatment (except biopsy, and no other oncological therapy)
3. Pre-existing psycho-morbid conditions precluding detialed Neurocognitive assessment and suitability for awake brain mapping
4. Contra-indication to surgery
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To create structural and functional cortical localization maps in Indian subjects undergoing brain tumor surgeries based on extra-operative (imaging and NCF) assessments , intraoperative (stimulation mapping) assessment and clinicopathological parameters.Timepoint: Preoperative
- Secondary Outcome Measures
Name Time Method 1. To correlate the extra-operative (imaging and NCF defined) and intra-operative (direct-electrical-stimulation confirmed) functional localization <br/ ><br>2. To compare maps of our Indian subjects with those published for other populations <br/ ><br>3. To assess NCF serially over the course of treatment and correlate the changes of NCF with patient/tumor and treatment related factors <br/ ><br>4. To create a repository of annotated multiparametric structural and functional brain data for future studies. <br/ ><br>Timepoint: 4 Weeks, 6 months and 1 year.