An open label randomised comparative clinical study to evaluate the comined effect of khadirtriphaladi kashaya & aragwadhadi kashaya with vamana in the management of ekakushtha vis a vis plaque psoriasis
试验速览
- 阶段
- Phase 3 4
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Reduction in scaling of ekakushtha vis a vis plaque psoriasi
研究概览
简要总结
In ayurveda, all skin diseases have been named under the general term kushtha. It is considered as one among the Ashtamahagada. Ekakushtha is vatakapha pradhana kshudra kushtha. Prathyatma lakshanas includes aswedana, mahavastu, matsyashakalopamam, krishna arunavarna. By looking at the lakshanas it can be correlated to plaque psoriasis.
Plaque psoriasis is the most common type of auto immune skin disease, the lesions are with red dry, slivery white scaling, which may be obivous after scraping the surface. The elbows, knees, and lower back are commonly involved.
According to who, the worldwide prevalence of psoriasis is 2% to 3%. In india the prevalence of psoriasis ranges from 0.44% to 2.8%.
In the contemporary system, the management of psoriasis is topical application,PUVA,corticosteriods and immunosuppresents which acts symptomatically
In present scenario it is more oftenly exacerbated with psychological and social impact. Hence is the need of time to find out safe and effective treatment for psoriasis. In Ayurveda, acharya Charaka explained snehapana, vamana, virechana, raktamokshana as line of treatment for kushta. Since Ekakushta is a type of Kshudrakushta with vatakapha pradhana dosha, hence snehapana us the first line of treatment mentioned in clasics which does vatashamana and vamana is best for kapha dosha nirharana. Shamana chikitsa includes Khadiratriphaladi kashaya and Aragwadhadi kashaya which acts as kaphahara and kushthagna.
In this present study effort is made to compare the efficacy of Kadhiratriphaladi kashaya and Aragwadhadi kashaya with vamana as kaphahara and kushthagna property.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Open Label
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)(—)
- 性别
- All
入选标准
- •Subjects presenting with lakashanas of ekakushtha Subjects presenting with isgns and symptoms of plaque psoriasis Subjects between age group of 18 to 60 years irrespective of gender.
排除标准
- •Subjects with other systemic and metabolic disorders such as diabetic mellitus,hypertension,thyroid dysfunction and cardio vascular diseases which interfere with the course of treatment.
- •Subjects under cortucosteriods and immuno suppressant medications.
- •Subjects associated with other skin disease like fungal infection, eczema, dermatitis.
- •Pregnant women and lactating mother Subjects unfit for vamana.
结局指标
主要结局
Reduction in scaling of ekakushtha vis a vis plaque psoriasi
时间窗: 6 weeks
次要结局
- Complete reduction in signs & symptoms of ekakushta vis a vis plaque psoriasis(6 weeks)
