Does Cold Provocation Increase Brown Adipose Tissue Volume?

Not Applicable

Completed

• Conditions: Brown Adipose Tissue, Human
• Interventions: Procedure: cold arm; Procedure: warm arm

• Registration Number: NCT01797328
• Lead Sponsor: University Hospital, Linkoeping

Brief Summary

About 28 healthy subjects are randomized to 1 hour/day of coldprovocation or to the best of ability to avoid feeling cold, for 6 weeks. Basal metabolic rate and magnetic resonance (for determination of brown adipose tissue volume) imaging are performed before and after the study.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-02
• Study First Submitted: 2013-02-18
• Study First Submitted QC: 2013-02-20
• Study First Posted: 2013-02-22
• Primary Completion: 2015-05
• Study Completion: 2015-06
• Results First Submitted: 2016-10-26
• Status Verified: 2017-04
• Results First Submitted QC: 2017-04-24
• Last Update Submitted: 2017-04-24
• Results First Posted: 2017-04-25
• Last Update Posted: 2017-04-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

healthy subjects -

Exclusion Criteria

any significant disease, ot other conditions that interferes with magnetic resonance imaging

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
cold provocation	cold arm	cold arm
to avoid feeling cold	warm arm	warm arm

Primary Outcome Measures

Name	Time	Method
Brown Adipose Tissue, Absolute Volume	Baseline and 6 week	Sub-clavicular brown adipose tissue volume by magnetic resonance imaging (liters)

Trial Locations

Locations (1)

Faculty of Health Science, Linköping; 🇸🇪 Linköping, Sweden