Comparative evaluation of premedication with oral Melatonin versus Pregabalin for attenuation of hemodynamic stress response to laryngoscopy and endotracheal intubation.
Phase 2
- Conditions
- Health Condition 1: K802- Calculus of gallbladder without cholecystitisHealth Condition 2: H701- Chronic mastoiditisHealth Condition 3: K429- Umbilical hernia without obstruction or gangrene
- Registration Number
- CTRI/2024/01/061064
- Lead Sponsor
- Dayanand Medical college and Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Adult patients of 18-65 years of age posted for elective surgeries under general anaesthesia.
American Society of Anaesthesiologists(ASA) class I-II.
Exclusion Criteria
1.Patients posted for emergency surgeries or hemodynamically unstable patients.
2.ASA III or IV patients
3.Patients with mallampati class III OR IV.
4.Patients diagnosed with sleep disorders.
5.Patients already taking sedatives,antipsychotics,anxiolytics,antiepileptic medications.
6.Pregnant or lactating patients.
7.Patient with known allergy to any of the study drug.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome is to compare the efficacy of oral melatonin versus pregabalin in attenuation of hemodynamic stress response to laryngoscopy & endotracheal intubationTimepoint: Hemodynamic parameters will be noted at the time of administration of study drug followed by every 30 minutes till 120 minutes of administration of drug then before laryngoscopy & endotracheal intubation after endotracheal intubation & then every minute till 10 minutes of endotracheal intubation.
- Secondary Outcome Measures
Name Time Method Secondary outcome will be measured as effect of premedication with oral melatonin versus pregabalin to allay the preoperative anxiety using VAS-A scale & to study any side effect associated with the study drugsTimepoint: Preoperative anxiety will be noted using VAS-A scale at the time of administration of study drug & after 120 minutes of administration of study drug