Resistance Exercise, Muscle Mass, Strength and Body Composition

Phase 3

Completed

• Conditions: Sarcopenia; Obesity
• Interventions: Other: HIT-exercise, low repetition range; Other: HIT-exercise, high repetition range; Other: HIT-exercise with protein; Other: Control

• Registration Number: NCT01766791
• Lead Sponsor: University of Erlangen-Nürnberg Medical School

Brief Summary

A plethora of trials reported the positive effect of resistance exercise on functional and morphological parameters. Although a large amount of the studies used suboptimum devices and obsolete methods the results of these older studies were still considered as golden standard. The aim of the present study is thus to determine the proper effect of different resistance exercise protocols with and without adjuvant protein supplementation on functional and morphological muscle and body composition parameters in male untrained subjects 30-50 years old under special regard of modern medical imaging and segmentation technologies.

Our general study hypothesis is that HIT-resistance exercise significantly impact relevant muscular parameters of the upper leg.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01
• Study First Submitted: 2013-01-07
• Study First Submitted QC: 2013-01-10
• Study First Posted: 2013-01-11
• Status Verified: 2014-03
• Primary Completion: 2014-03
• Study Completion: 2014-03
• Last Update Submitted: 2014-03-20
• Last Update Posted: 2014-03-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 120

Inclusion Criteria

• males
• untrained (< 2 h exercise/week, < 1 h resistance exercise/week)
• 30-50 years old

Exclusion Criteria

• medication/diseases affecting intervention or study endpoints
• history of intense resistance exercise (> 3 h/week during the last decade)
• very low physical capacity (< 100 Watt at ergometry)
• more than 2 weeks of absence during the interventional period
• contraindication related to MRI-assessment (i.e. magnetizable intracorporal artefacts)
• pathological changes of the heart
• inflammable diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
HIT-exercise, low repetition range	HIT-exercise, low repetition range	High Intensity Resistance Exercise Training, low repetition range, \> 75% 1 Repetition Maximum (1RM)
HIT-exercise, high repetition range	HIT-exercise, high repetition range	High Intensity Resistance Exercise Training, high repetition range, 60 - \<75% 1RM
HIT-exercise with protein	HIT-exercise with protein	High Intensity Resistance Exercise Training with protein supplementation
Control	Control	No physical exercise intervention

Primary Outcome Measures

Name	Time	Method
fat free Cross Sectional Area (CSA) upper leg	change from baseline in fat free Cross Sectional Area at 5 months	fat free muscle cross sectional area of the upper leg at mid-femur via Quantitative Computed Tomography (QCT)

Secondary Outcome Measures

Name	Time	Method
CSA upper leg	change from baseline in CSA upper leg at 5 months	muscle cross sectional area of the upper leg at mid-femur via QCT

Trial Locations

Locations (1)

Institute of Medical Physics, University of Erlangen-Nurnberg; 🇩🇪 Erlangen, Germany