Effects of Resistance Exercise on Muscle Mass, Strength, Body Composition and Heart in Men 30-50 Years Old.
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- fat free Cross Sectional Area (CSA) upper leg
研究概览
简要总结
A plethora of trials reported the positive effect of resistance exercise on functional and morphological parameters. Although a large amount of the studies used suboptimum devices and obsolete methods the results of these older studies were still considered as golden standard. The aim of the present study is thus to determine the proper effect of different resistance exercise protocols with and without adjuvant protein supplementation on functional and morphological muscle and body composition parameters in male untrained subjects 30-50 years old under special regard of modern medical imaging and segmentation technologies.
Our general study hypothesis is that HIT-resistance exercise significantly impact relevant muscular parameters of the upper leg.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 30 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •untrained (< 2 h exercise/week, < 1 h resistance exercise/week)
- •30-50 years old
排除标准
- •medication/diseases affecting intervention or study endpoints
- •history of intense resistance exercise (> 3 h/week during the last decade)
- •very low physical capacity (< 100 Watt at ergometry)
- •more than 2 weeks of absence during the interventional period
- •contraindication related to MRI-assessment (i.e. magnetizable intracorporal artefacts)
- •pathological changes of the heart
- •inflammable diseases
结局指标
主要结局
fat free Cross Sectional Area (CSA) upper leg
时间窗: change from baseline in fat free Cross Sectional Area at 5 months
fat free muscle cross sectional area of the upper leg at mid-femur via Quantitative Computed Tomography (QCT)
次要结局
- CSA upper leg(change from baseline in CSA upper leg at 5 months)