Comparison between pressure regulated volume-controlled (PRVC) and volume-controlled (VC) ventilation on oxygenation parameters, airway pressures and

Not Applicable

• Conditions: Respiratory; Surgery; One lung ventilation during thoracic surgery

• Registration Number: PACTR201512001388104
• Lead Sponsor: Minoufiya University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-12-13
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

adult patients ASA I-III undergoing elective open thoracic surgery using one lung ventilation.

Exclusion Criteria

Preoperative exclusion criteria will include patient refusal, significant lung diseases {forced expiratory volume in 1 s (FEV1) or vital capacity (VC) < 50% of the predicted values}, uncompensated cardiac disease or mean pulmonary artery pressure (MPAP) > 30 mm Hg, hepatic or renal disease, coagulation disorders or a history of pre-operative immuno-suppressant medications. Intraoperative exclusion criteria will include inability to maintain an appropriate arterial oxygen saturation(SpO2) and end-tidal carbon dioxide (EtCO2), inability to keep stable mechanical ventilation settings for 30 min, , abnormal surgical complications, and prolonged hemodynamic instability

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
arterial, and central venous blood gases, Pa O2/FIO2 ratio, dead space volume/tidal volume (VD/VT) ratio, peak inspiratory pressure (Ppeak), mean inspiratory pressure (Pmean), and plateau inspiratory pressure (Plateau),