The Effect of Coffee on People with High Intensity Exercise and the Characteristics of Caffeine Metabolism

Not Applicable

Recruiting

• Conditions: Healthy

• Registration Number: NCT06712667
• Lead Sponsor: Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences

Brief Summary

The purpose of this project is to explore the relationship between the effect of coffee on exercise performance and caffeine metabolism.

Detailed Description

The investigators will study the relationship between the impact of coffee on exercise and caffeine metabolism. The investigators will recruit healthy elite athletes. Participants will be forbidden to consume stimulant drinks such as coffee for 24 hours before the experiment. When the participants arrive at the lab on the day of the experiment, they will sign an informed consent form, a health history questionnaire and a daily coffee consumption questionnaire. Each participant does six rides, with one day of caffeine washout before each ride. In all trials, each participant will ride at the same time of day. Before riding, drink 200 ml water, decaffeinated coffee or coffee in random order, and the caffeine content of coffee is 200 mg. After 60 minutes of drinking, they start riding, after the completion of the riding, the subjects perceived and judged the perception between the baseline load and the comparison load. After the completion of the judgment, the next level of stimulus parameters will randomly generated to conduct the experiment. Each person conducted 6 groups of intervention experiments. Changes in average exercise performance, heart rate, electrocardiogram and body temperature will be observed after drinking decaffeinated coffee or coffee compared with drinking water. The concentration of caffeine and its metabolites in urine before and after drinking within 3 hours will be measured by liquid chromatography-mass spectrometry (LC-MS) or gas chromatography-mass spectrometry (GC-MS).

Study Timeline

• Study Start: 2024-10-23
• Status Verified: 2024-11
• Study First Submitted: 2024-11-26
• Study First Submitted QC: 2024-11-26
• Study First Posted: 2024-12-02
• Last Update Submitted: 2025-02-25
• Last Update Posted: 2025-02-26
• Primary Completion: 2029-06-30
• Study Completion: 2029-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Healthy adults 18-40 years old

Exclusion Criteria

Diabetes Hypoglycemia Gout Osteoporosis Gastric ulcer Pancreatitis Intestinal obstruction Blood phobia Pathological hypo or hyper tension Impaired glucose tolerance Claustrophobia HIV,etc.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Exercise performance	On the experimental day, it lasts 2 weeks.	After the completion of the riding, the subjects perceived and judged the perception between the baseline load and the comparison load.
Urine metabolites	On the experimental day, it lasts 2 weeks.	The contents of metabolites will be measured by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS ).

Secondary Outcome Measures

Name	Time	Method
Body temperature	On the experimental day, it lasts 2 weeks.	Body temperature of participants will be measured by ear temperature gun.
Electrocardiogram (ECG)	On the experimental day, it lasts 2 weeks.	ECG of participants will be measured by Amu ECG belt, the changes in P wave, PR interval, PR segment, QRS wave group, J point, ST segment, T wave, QT interval, and U wave will be observe.
Blood pressure	On the experimental day, it lasts 2 weeks.	Systolic and diastolic blood pressure of participants will be measured by Omron digital sphygmomanometer.
Height	The morning of the first day of the experiment, 5 mins	Height will be measured by seca 217 stable stadiometer. Subjects wearing no shoes.
Body weight	The morning of the first day of the experiment, 5 mins	Fasting body weight will be measured by Bioimpedance Analysis (TANITA, MC-980).
Fat mass	The morning of the first day of the experiment, 10 mins	Fat mass will be measured by Magnetic Resonance Imaging (Shanghai united imaging, uMR 790 ).
Fat free mass	The morning of the first day of the experiment, 10 mins	Fat free mass will be measured by Bioimpedance Analysis (Tanita, MC-980).
Bone mass	The morning of the first day of the experiment, 10 mins	Bone mass will be measured by Dual Energy X-ray Absorptiometry (Horizon Wi).
Heart rate	2 weeks	Heart rate will be measured by heart rate belt.
Waist circumferences	The morning of the first day of the experiment,10 mins	Waist circumferences will be measured using a whole body laser scanner (TG2000-F).

Trial Locations

Locations (1)

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences; 🇨🇳 Shenzhen, Guangdong, China