NL-OMON56593招募中不适用
A comparison of nigrostriatal dopaminergic functioning in healthy adults of West-African and European descent - The relationship between ancestry and dopamine in the brain
Amsterdam UMC0 个研究点目标入组 80 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •1. Age 18-70 years old.
- •2. West-African or Dutch descent, as determined through self-report (parents
- •and grandparents should be born in the corresponding region). After the study
- •has been conducted, ancestry will be confirmed with genetic analysis.
- •3. Speaks Dutch or English.
排除标准
- •1. Present or past (suspected) presence of severe psychiatric illness, such as
- •schizophrenia or other psychotic disorder, bipolar disorder, depressive
- •disorder with psychotic features.
- •2. Present or past (suspected) presence of neurological disorder (e.g.,
- •Parkinson*s disease, epilepsy), evidence of brain damage, and/or other medical
- •illness (e.g., diabetes mellitus) that may affect brain function.
- •3. Current or recent (past three months) use of illicit drugs, as determined by
- •self-report and with a urinary drug test on the day of neuroimaging (the
- •results of this drug test will be checked after the participant has completed
- •the study). Participants will be tested on use of cannabis, amphetamines, XTC,
- •cocaine and opiates.
- •4. Lifetime use of illicit drugs (in particular opiates, amphetamines, XTC, and
- •cocaine; exclusion for other illicit drug use will be decided on a case-by-case
- •basis), if frequently taken (>10x lifetime use of drugs).
- •5. Lifetime cannabis use, if frequently taken (weekly use for at least a year).
- •6. Current or recent (past three months) use of dopamine-altering
- •medications/drugs that might influence neuroimaging of DAT availability,
- •namely: amphetamines, cannabis, cocaine, CNS stimulants phentermine or
- •ephedrines, modafinil, certain antidepressants (mazindol, bupropion,
- •radafaxine), adrenergic agonists, anticholinergic drugs, opioids, anesthetics
- •ketamine, PCP, or isoflurane.
- •7. Smoking or consuming caffeinated drinks during the period of six hours prior
- •to the DAT SPECT scan.
- •8. Participation in a scientific examination that used radiation, in the last
- •9. (Non-removable) metal objects in or around the body.
- •10. In women: pregnancy (self-report or positive pregnancy test) and/or
研究者
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