Ultrasound Findings of Finger, Wrist and Knee Joints in Mucopolysaccharidosis

Completed

• Conditions: MPS I; MPS IV

• Registration Number: NCT02067650
• Lead Sponsor: Children's Hospital of Eastern Ontario

Brief Summary

Hardly any imaging studies specifically addressing the articular and periarticular structures in MPS patients are available at this point. The investigators propose to do for the first time a pilot study using musculoskeletal ultrasound in patients with various types of MPS.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-08-13
• Study Start: 2013-09
• Study First Submitted QC: 2014-02-19
• Study First Posted: 2014-02-20
• Primary Completion: 2016-03
• Study Completion: 2016-12
• Status Verified: 2018-01
• Last Update Submitted: 2018-01-23
• Last Update Posted: 2018-01-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Power Doppler	one time exam	The primary objective is to determine whether patients with various types of MPS and at various stages of the disease exhibit abnormalities of the finger, wrist and knee joints as assessed by grey scale and Power Doppler ultrasonography.

Secondary Outcome Measures

Name	Time	Method
Ultrasound scanning technique	one time scan	To determine the optimal ultrasound scanning technique for MPS patients given the potentially advanced joint contractures
Findings of synovitis or tenosynovitis	one time scan	To determine whether there are ultrasound findings indicative of synovitis or tenosynovitis
Differences between MPS I and IV	one time scan	To determine whether differences exist between MPS I and MPS IV
Differences between ERT and BMT	one time scan	To determine whether differences exist between patients with or without Enzyme Replacement Therapy (ERT) or Bone Marrow Transplants
Differences between severe and attenuated phenotypes	one time scan	To determine whether differences exist between severe and attenuated phenotypes

Trial Locations

Locations (1)

Children's Hospital of Eastern Ontario; 🇨🇦 Ottawa, Ontario, Canada