Genetic modifiers of cardiac electrophysiology in a large Dutch family with the SCN5A 1795insD mutatio
- Conditions
- primary arrhythmia syndromes - heritable heart rhythm disorders1000752110083624
- Registration Number
- NL-OMON30585
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 70
Inclusion Criteria
Having conceived 1 or more children carrying the SCN5A 1795insD mutation with someone who is also carrying this mutation (i.e. the individual is a spouse and parent of a mutation carrier)
Exclusion Criteria
No informed consent
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The discovery of genetic modifiers which are associated with the cardiac<br /><br>electrical phenotype and SCD may allow improved risk stratification and<br /><br>individualised tailoring of preventive and therapeutic treatment not only for<br /><br>the SCN5A 1795insD family but also for other populations at risk for SCD.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable.</p><br>