Cardiovascular Responses to Exercise in People Living With HIV/AIDS: Effects of Exercise Training
- Conditions
- HIV Infections
- Interventions
- Behavioral: Exercise training
- Registration Number
- NCT04512456
- Lead Sponsor
- Instituto Nacional de Cardiologia de Laranjeiras
- Brief Summary
Patients living with HIV (PLWHIV) have compromised muscle metaboreflex, which can cause exercise intolerance. This randomized controlled clinical trial will verify the effects of regular exercise on autonomic and hemodynamic responses to muscle ergoreflex activation in these patients. PLWHIV without regular physical exercise will be randomly assigned into an exercise training or a control group. The exercise training group will undergo regular physical exercise during 12 weeks (60-min session performed 3 times/wk with moderate intensity), while the control group will keep inactive. Another group consisted of inactive HIV-uninfected group will be included. The primary endpoints will be blood pressure and autonomic markers in response to the Stroop Color-Word Test and the activation of muscle ergoreflex, by means of the post-exercise circulatory arrest (PECA), which will be performed with and without the topical application of a capsaicin-based analgesic balm. Secondary endpoints will include heart rate, peripheral vascular resistance, stroke volume, cardiac output, blood lactate concentration, anthropometrics, and handgrip strength. The active and inactive PLWHIV groups will be evaluated before and after the exercise training, while the healthy group only at baseline.
- Detailed Description
HIV-infection is associated to a reduced maximal cardiac output and blunted pressor reflex response to static handgrip exercise, which are suggestive of impaired ergoreflex activation. An abnormal ergoreflex activation may lead to exercise intolerance and increases in cardiovascular risk. Despite the importance of therapeutic strategies in reducing the cardiovascular risk among patients living with HIV, exercise-related effects on ergoreflex sensitivity in these population have not been previously investigated.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 63
Not provided
- regular physical exercise;
- malnutrition;
- presence of coronary artery disease, ischemic diseases, pulmonary disease, diabetes, Chagas disease, tuberculosis, heart failure, hypertension;
- using pacemakers and/or antidepressant, antiarrhythmic or antihypertensive medication, especially beta-blockers.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Active HIV-infected patients Exercise training Exercise training
- Primary Outcome Measures
Name Time Method Change from Baseline Blood Pressure at 3 months Baseline and 3 months of follow-up Blood pressure will be assessed by a digital sphygmomanometer.
Change from Baseline Heart Rate Variability at 3 months Baseline and 3 months of follow-up Heart rate variability will be assessed by a heart rate monitor.
- Secondary Outcome Measures
Name Time Method Change from Baseline Heart Rate at 3 months Baseline and 3 months of follow-up Heart rate will be evaluated beat-to-beat by means of a heart rate monitor.
Change from Baseline Peripheral Vascular Resistance at 3 months Baseline and 3 months of follow-up Peripheral Vascular Resistance will be evaluated by photpletismography.
Change from Baseline Stroke Volume at 3 months Baseline and 3 months of follow-up Stroke Volume will be evaluated by photoplethysmography.
Change from Baseline Cardiac Output at 3 months Baseline and 3 months of follow-up Cardiac Output will be evaluated by photoplethysmography.
Change from Baseline Blood Lactate at 3 months Baseline and 3 months of follow-up. Blood Lactate will be determined by the YSL 2700 analyzer.
Change from Baseline Anthropometric markers at 3 months Baseline and 3 months of follow-up. Anthropometric markers will be determined by a digital scale and wall-mounted stadiometer.
Change from Baseline handgrip maximal voluntary contraction at 3 months Baseline and 3 months of follow-up. Handgrip maximal voluntary contraction will be assessed using a hydraulic handgrip dynamometer.
Trial Locations
- Locations (1)
Rio de Janeiro State University
🇧🇷Rio de Janeiro, RJ, Brazil