The Effects of Exercise Training in Vascular Function of Patients Living With HIV
- Conditions
- HIV/AIDS
- Interventions
- Behavioral: Exercise
- Registration Number
- NCT03343522
- Lead Sponsor
- Instituto Nacional de Cardiologia de Laranjeiras
- Brief Summary
Introduction: It is well known that the infection caused by the Human Immunodeficiency Virus (HIV) is associated to a higher cardiovascular event risk. On the other hand, it is clear that the aerobic exercise training induces improvements in autonomic control and vascular function, through increases in vasodilator agents and blood vessels number. However, the investigators could not find previous works that studied the microvascular function in response to exercise training in HIV patients.
Objectives: To study the impact of aerobic exercise training in endothelial function of HIV patients. In addition, the investigators will verify the association of the physical fitness to the nitric oxide bioavailability, angiogenesis and lipid profile in HIV patients.
Methods: The study subjects will be composed by HIV patients, that will be randomly divided in two different groups: exercised and sedentary. The subjects will be tested before and after training in regards to endothelial function, nitric oxide bioavailability, physical fitness and lipid profile, through flowmetry, colorimetric essays, maximal cardiopulmonary exercise test, and biochemical tests; respectively. The exercise training will be performed in a treadmill for 12 weeks, 3 times a week, 40 minutes each section.
Expected Results: The investigators expect to achieve markers that will help in understanding the interaction of HIV with several factors that contribute to an increased endothelial function after exercise training.
- Detailed Description
HIV-infection triggers a massive oxygen reactive species production, increasing oxidative stress and vascular complications. Despite the importance of therapeutic strategies in reducing the cardiovascular risk among HIV-infected patients (HIVP), exercise-related effects upon macro-and-microvascular endothelial function and oxidative stress in HIVP have not been previously reported.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
- sedentarism for at least 6 months;
- diagnosis of HIV infection.
- opportunistic diseases;
- nephropathies;
- cardiovascular diseases;
- locomotor limitations;
- liver diseases.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Exercise Training Exercise Patients assigned to this arm will be enrolled in exercise training program.
- Primary Outcome Measures
Name Time Method Skin microvascular blood flow Baseline and 3 months Microvascular reactivity will be evaluated by laser speckle contrast imaging with laser wavelength of 785 nm in combination with iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) for noninvasive and continuous measurements of cutaneous microvascular flow changes in the forearm.
- Secondary Outcome Measures
Name Time Method Peak Oxygen consumption Baseline and 3 months Measured at a maximal graded exercise test.
Body fat Baseline and 3 months Dual-energy X-ray absorptiometry.
Forearm macrovascular blood flow Baseline and 3 months Forearm macrovascular blood flow will be evaluated by venous occlusion plethysmography.
Nitrite/nitrate Baseline and 3 months Colorimetric assay kit
Capillary density Baseline and 3 months Capillary density will be evaluated by high-resolution intra-vital color microscopy.
Trial Locations
- Locations (1)
Rio de Janeiro State University
🇧🇷Rio De Janeiro, RJ, Brazil