Relationship between radiation-induced oral mucositis and the oral bacterial flora with undergoing radiotherapy: A prospective study
- Conditions
- Head and neck cancer patients
- Registration Number
- JPRN-UMIN000050646
- Lead Sponsor
- Gunma University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 66
Not provided
1) Previous radiation therapy to the area to be treated. 2) Active and refractory infection at the irradiated site. (3) Severe complications (uncontrolled diabetes, myocardial infarction, unstable angina, uncontrolled arrhythmia, bleeding tendency, collagen disease requiring steroid administration, etc.). (4) Active multiple cancers (simultaneous multiple cancers and iatrogenic multiple cancers with a disease-free interval of 5 years or less). However, lesions equivalent to intraepithelial or intramucosal carcinoma that are considered curable by local treatment are not included in the active overlapping cancers. (5) Previous surgery in the radiotherapy area. (6) An event occurs during the study period for which radiotherapy should not be initiated. (7) The patient is found not to have a malignant tumor in the head and neck region after the start of the study. (8) If it becomes difficult to continue radiotherapy for some reason after the start of the study. (9) Other medical, psychological, or other factors that make the physician in charge of the patient inappropriate for the study.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To observe the change in oral bacterial flora during radiotherapy and investigate the relationship between the type of specific bacterias and the onset of radiation induced mucositis.
- Secondary Outcome Measures
Name Time Method