Long-term Follow-up of Gene Therapy for Radiation-Induced Xerostomia
- Conditions
- Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
- Interventions
- Genetic: AAV2-hAQP1
- First Posted Date
- 2024-08-09
- Last Posted Date
- 2024-08-09
- Lead Sponsor
- MeiraGTx, LLC
- Target Recruit Count
- 120
- Registration Number
- NCT06544798
- Locations
- ๐บ๐ธ
Atrium Health, Charlotte, North Carolina, United States
A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia
- Conditions
- Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
- Interventions
- Other: PlaceboGenetic: AAV2-hAQP1 Concentration 2Genetic: AAV2-hAQP1 Concentration 1
- First Posted Date
- 2023-07-03
- Last Posted Date
- 2024-10-08
- Lead Sponsor
- MeiraGTx, LLC
- Target Recruit Count
- 120
- Registration Number
- NCT05926765
- Locations
- ๐บ๐ธ
City of Hope, Duarte, California, United States
๐บ๐ธHenry Ford Health, Detroit, Michigan, United States
๐บ๐ธUNC-Chapel Hill, Chapel Hill, North Carolina, United States
Long-term Follow-up of Glutamic Acid Decarboxylase (GAD) Gene Transfer in Parkinson's Disease
- Conditions
- Parkinson Disease
- Interventions
- Genetic: AAV-GAD
- First Posted Date
- 2023-06-08
- Last Posted Date
- 2024-08-06
- Lead Sponsor
- MeiraGTx, LLC
- Target Recruit Count
- 14
- Registration Number
- NCT05894343
- Locations
- ๐บ๐ธ
Yale University, New Haven, Connecticut, United States
๐บ๐ธHenry Ford West Bloomfield Hospital, West Bloomfield, Michigan, United States
๐บ๐ธWeill Cornell Medicine, New York, New York, United States
A Double-blind Study to Evaluate the Safety of Glutamic Acid Decarboxylase Gene Transfer in Parkinson's Participants
- Conditions
- Parkinson Disease
- Interventions
- Genetic: AAV-GAD Dose 2Genetic: AAV-GAD Dose 1Procedure: Sham Surgery
- First Posted Date
- 2022-11-02
- Last Posted Date
- 2024-10-08
- Lead Sponsor
- MeiraGTx, LLC
- Target Recruit Count
- 14
- Registration Number
- NCT05603312
- Locations
- ๐บ๐ธ
Henry Ford West Bloomfield Hospital, West Bloomfield, Michigan, United States
๐บ๐ธWeill Cornell Medicine, New York, New York, United States
๐บ๐ธColumbia University Irving Medical Center, New York, New York, United States
Long-Term Follow-Up Study of AAV2hAQP1 for Radiation Induced Xerostomia
- Conditions
- Radiation-induced Xerostomia
- First Posted Date
- 2021-09-29
- Last Posted Date
- 2024-04-17
- Lead Sponsor
- MeiraGTx, LLC
- Target Recruit Count
- 22
- Registration Number
- NCT05060341
- Locations
- ๐บ๐ธ
Leland Stanford Junior University, Stanford, California, United States
๐บ๐ธBrigham and Women's Hospital, Boston, Massachusetts, United States
๐บ๐ธAtrium Health, Charlotte, North Carolina, United States
Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction
- Conditions
- Radiation Induced XerostomiaSalivary HypofunctionSquamous Cell Head and Neck Cancer
- Interventions
- First Posted Date
- 2015-05-18
- Last Posted Date
- 2023-08-18
- Lead Sponsor
- MeiraGTx, LLC
- Target Recruit Count
- 17
- Registration Number
- NCT02446249
- Locations
- ๐บ๐ธ
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States