Het effect van een bloedtransfusie bij kritiek zieke patiënte
- Conditions
- EN: red blood cell transfusion, clearance, microcirculation, sepsis, intensive care medicineNL: rode bloedcel transfusie, klaring, microcirculatie, sepsis, intensive care
- Registration Number
- NL-OMON27009
- Lead Sponsor
- Academic medical centre Amsterdam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 86
Inclusion Criteria
Patients must receive an erythrocyte transfusion on the ICU, to correct for anemia
- Patients may not have received a transfusion with red blood cells, plasma or thrombocytes in the previous 24 hours
Exclusion Criteria
- Patients who have not given informed consent
- Patients who pose difficulties in securing blood products (e.g. rare blood groups)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Phosphatidylserine exposure on donor RBCs
- Secondary Outcome Measures
Name Time Method - Clearance of erythrocytes<br /><br>- Expression of clearance markers other than PS <br /><br>- Markers of immune cell and endothelial cell activation and adhesion <br /><br>- Complete blood count<br /><br>- Levels of fibrinogen, APTT, PTT and D-dimers in blood (to calculate DIC score)<br /><br>- Markers of inflammatory host respons <br /><br>- Sublingual microcirculatory density and perfusion velocity, as visualized with SDF <br /><br>- Tissue oxygenation, as measured with NIRS<br /><br>- Time on mechanical ventilation<br /><br>- Duration of ICU stay<br /><br>- Duration of hospital stay<br /><br>- 28 day mortality<br /><br>- DNA staining on residual red blood cell material, <br /><br>- Red blood cell deformability, activation status and cell-binding ability<br /><br>- Oxygen tension in the mitochondria (MitoPO2)<br>