Hepatic Blood Flow Changes During Fluid Challenge Assessed by MRI in Volunteers Subjects.

Not Applicable

Completed

• Conditions: Hepatic Flow Changes
• Interventions: Device: MRI (magnetic resonance imaging)

• Registration Number: NCT03589261
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Hepatic artery and portal flows are both regulated to assume the whole hepatic blood flow. Each counts for respectively 25% and 75%. That so-called "buffer response" assumes that when portal flow increases, hepatic artery flow decreases. During fluid challenge in intensive care unit, fluid challenge is often administered to improve hepatic perfusion. That observation is not demonstrated. The aim of the study is to test buffer response and portal flow during fluid challenge.

Detailed Description

Prospective monocentric study at Amiens Hospital University. 20 volunteers subjects will be include after providing informed consent. Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI.

Study Timeline

• Study First Submitted: 2018-07-03
• Study First Submitted QC: 2018-07-16
• Study First Posted: 2018-07-17
• Study Start: 2018-09-06
• Primary Completion: 2019-03-29
• Study Completion: 2019-03-29
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-01
• Last Update Posted: 2019-04-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• Fasting for the last 12 hours.

Exclusion Criteria

• Claustrophobia
• Any previous medical history disease;
• Any abdominal surgical disease
• Pregnancy or breastfeeding

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
MRI (magnetic resonance imaging)	MRI (magnetic resonance imaging)	Hepatic blood flow baseline will be measured using MRI. Fluid challenge of 500 ml of NaCl 0.9% will be administered during 10 minutes. Before and After fluid challenge, MRI will be performed to compare flow changes.

Primary Outcome Measures

Name	Time	Method
Portal blood flow measure before and after fluid challenge	Two hours: the difference in hepatic portal flow before and after a volume expansion of 500 ml NaCl 0.9%.	Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI (magnetic resonance imaging).

Secondary Outcome Measures

Name	Time	Method
Hepatic artery blood flow measure before and after fluid challenge	Two hours	Hepatic artery blood flow measure before and after a volume expansion of 500 ml NaCl 0.9%.

Trial Locations

Locations (1)

CHU Amiens-Picardie; 🇫🇷 Amiens, France