跳至主要内容
临床试验/NCT01773694
NCT01773694已完成不适用

Impact of Early Post-Operative Water Exposure on Complications of Cutaneous Surgeries

Milton S. Hershey Medical Center2 个研究点 分布在 1 个国家目标入组 507 人开始时间: 2013年3月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
507
试验地点
2
主要终点
Post-operative wound infection

研究概览

简要总结

Patients are often counseled to keep a surgical wound dry for 2 to 3 days. The rationale is likely to decrease the risk of infection and bleeding. However, this has never been formally studied. Patient's routines are likely disrupted when they are asked to avoid wetting the area. The investigators will perform a controlled study to determine if avoidance of post-operative wetting is necessary.

详细描述

Physicians commonly instruct their patients to keep a wound dry for 2 to 3 days following surgery. The rationale may be that sources of water like a shower, bathtub, or swimming pool may increase the risk of infection. There may also be a concern that changing a dressing in the early post-operative period will increase the risk of bleeding complications. However, patient's routines and quality of life are disrupted when they are asked to avoid bathing, exercise, and swimming.

These issues have never been formally studied. This study will test the hypothesis of whether early post-operative wetting will have any influence on infection rates, bleeding complications, or the appearance of a surgical wound. Patients presenting to the Penn State Hershey dermatology clinic for the surgical removal of cancerous or non-cancerous skin lesions will be invited to participate. There will be no change to the standard surgical treatment. The dressing will be the same for all study participants. After surgery, study subjects who consent to participate will be randomized to receive one of two sets of post-operative instructions. One group will be directed to keep their initial post-operative dressing intact and dry for 48 hours. The second group will remove the dressing at 6 hours and wet the wound for 10 minutes in whatever manner they choose (shower, bath, pool, hot tub, etc.). After the initial dressing is removed (at 48 hours or 6 hours), both groups will perform identical post-operative care, consisting of cleansing the wound with soap and water followed by the application of petrolatum ointment and a dry dressing.

All participants will follow-up 7 to 14 days after surgery or earlier if they are experiencing any problems. At this time, the site will be assessed for clinical evidence of infection and bleeding. If the former is present, a bacterial culture will be obtained to confirm a wound infection and patients will be treated with an antibiotic. Physicians performing the assessment will be blinded to the patient's status (early wetting group or not). All subjects will also complete a questionnaire inquiring how and when they wet their wounds after surgery as well as two questionnaires asking how their quality-of-life and function were affected. Participants will again follow-up at 6 months when a blinded investigator will assess the cosmetic appearance of the scars using an established scar rating tool.

The data from this study will provide valuable evidence based guidance to surgeons in drafting wound care instructions for their patients. If the hypothesis proves correct, patients may be spared the inconvenience of post-operative water avoidance, diminishing the disruption to their lives caused by skin surgery.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Triple (Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • subjects are capable of giving informed consent
  • patients undergoing any surgical treatment of benign and malignant lesions by any physician in the Dermatology department consisting of:
  • standard excisional surgery or Mohs micrographic surgery with immediate reconstruction
  • reconstruction with primary linear closure or adjacent tissue transfer with one or two layers of suture

排除标准

  • age younger than 18 years
  • will not be returning to the dermatology clinic in 7-14 days for suture removal
  • documented or suspected infection of the site prior to surgery
  • current treatment with systemic antibiotic therapy
  • staged excisions
  • delayed or staged reconstructions
  • wounds repaired with skin or cartilage grafts
  • management with secondary intention healing
  • surgical site on or near a mucosal surface where standard dressings are not typically used (eyelid, vermilion, etc.)
  • patients receiving prophylactic antibiotics
  • patients deemed on a case-by-case basis by their surgeon to have a high risk of post-operative bleeding and requiring prolonged application of a pressure dressing
  • history of skin sensitivity or reaction to white petrolatum

结局指标

主要结局

Post-operative wound infection

时间窗: Post-operative day 7 to 14

次要结局

  • Incidence of post-operative bleeding complications(Post-operative day 7 to 14)
  • Scar appearance(6 months post-operatively (+-5 days))
  • Skin Specific Quality of Life(Post-operative days 7 to14)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Todd V Cartee

Associate Professor of Dermatology

Milton S. Hershey Medical Center

研究点 (2)

Loading locations...

相似试验