Glucose Metabolism and Sleep in People With Family History of Type 2 Diabetes.

Completed

• Conditions: Sleep; Insulin Resistance; Type 2 Diabetes

• Registration Number: NCT00720889
• Lead Sponsor: University of Chicago

Brief Summary

The use of sugar and starch-like foods for energy (carbohydrate metabolism) changes when people sleep. However, it is still not known if differences in the amount of nighttime sleep have an effect on the carbohydrate metabolism of people who have a relative with type 2 diabetes (parent, sibling, or grandparent). This study is being done to test the hypothesis that individual differences in habitual sleep duration may be related to differences in the carbohydrate metabolism of people who have a history of type 2 diabetes in their family.

Detailed Description

On two consecutive inpatient days, the participants in this study will undergo two different tests. The first test will determine how much insulin can their body produce in response to an intravenous glucose infusion over a period of several hours. The second test will determine how effective is the action of the sugar-processing hormone, insulin, in their body when it is infused intravenously together with glucose over a period of several hours.

Study Timeline

• Study Start: 2008-07
• Study First Submitted: 2008-07-21
• Study First Submitted QC: 2008-07-21
• Study First Posted: 2008-07-23
• Primary Completion: 2012-03
• Study Completion: 2012-03
• Status Verified: 2013-09
• Last Update Submitted: 2013-09-04
• Last Update Posted: 2013-09-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• regular sleep habits
• BMI 20 to 27 kg/m2
• at least one parent, sibling or grandparent with type 2 diabetes
• no regular exercise habits

Exclusion Criteria

• active smoker
• night or shift work
• have highly variable sleep habits
• have a hormonal disorder
• have a sleep disorder
• have an active medical problem
• women only: use of birth control pills
• women only: irregular menstrual periods or pregnancy
• use of medications/compounds that can disrupt sleep

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total body insulin sensitivity	at the end of a 4-hour hyperinsulinemic clamp

Secondary Outcome Measures

Name	Time	Method
First and second phase insulin secretion	during a 3-hour hyperglycemic clamp
Endogenous glucose production	before and during a 4-hour hyperinsulinemic clamp
Glycerol turnover and free fatty acid concentration	before and during a 4-hour hyperinsulinemic clamp

Trial Locations

Locations (1)

University of Chicago; 🇺🇸 Chicago, Illinois, United States