Randomised trial of vitamin D and calcium for the secondary prevention of osteoporosis related fractures in the elderly
Completed
- Conditions
- Primary careMusculoskeletal DiseasesOsteoporosis with pathological fracture
- Registration Number
- ISRCTN51647438
- Lead Sponsor
- Medical Research Council (MRC) (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 5250
Inclusion Criteria
1. Aged 70 years or over (irrespective of sex)
2. Recent first proximal femoral or other appendicular fracture sustained in a fall or clinical vertebral fracture
3. Attending fracture clinic or hospital in-patient
4. Resident in UK
5. Able to comply with protocol (eg Mini-mental Score greater than 7)
6. Gives consent
Exclusion Criteria
1. Multiple or high energy transfer injury
2. Inability to walk prior to presenting fracture without the support of others
3. Suffering from known malignant disease
4. Contraindication to Calcium or Vitamin D
5. Current or recent treatment with more than 200iu daily of Vitamin D, Calcium, Fluoride, Diphosphonate or Calcitonin
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. New fractures, <br>2. Cost per avoided new fracture<br>3. Quality of life gain
- Secondary Outcome Measures
Name Time Method ot provided at time of registration