Gut Microbiota, "Spark and Flame" of COVID-19 Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 115
- 试验地点
- 3
- 主要终点
- Differences in gut microbiota composition between COVID-19 patients with different degrees of disease severity.
研究概览
简要总结
Elderly, hypertension, diabetes and cardiovascular diseases are risk factors for COVID-19 morbility and mortality. However, the real reason for this is not yet understood. It is well documented that gut microbiota has a critical role in health, particularly in the immune system and therefore, we propose that gut microbiota composition could affect vulnerability and disease outcomes of COVID-19.
详细描述
In order to explore this hypothesis, we will analyse the gut microbiota of SARSCoV-2 infected patients categorized according to location: [1] ambulatory (self-isolation at home), [2] ward and [1] ICU; and severity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults of 18 years and above.
- •COVID-19 patients.
排除标准
- 未提供
结局指标
主要结局
Differences in gut microbiota composition between COVID-19 patients with different degrees of disease severity.
时间窗: Stool samples of COVID-19 patients will be collected after subject enrollment (single point collection)
次要结局
- Differences in gut microbiota composition between COVID-19 patients in relation to mortality.(Through study completion, an average of 3 months.)
- Differences in gut microbiota composition between COVID-19 patients in relation to length of stay in hospitals.(Through study completion, an average of 3 months.)
- Differences in gut microbiota composition between COVID-19 patients in relation to duration of mechanical ventilation.(Through study completion, an average of 3 months.)