Gut Microbiota, "Spark and Flame" of COVID-19 Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COVID-19
- Sponsor
- Universidade Nova de Lisboa
- Enrollment
- 115
- Locations
- 3
- Primary Endpoint
- Differences in gut microbiota composition between COVID-19 patients with different degrees of disease severity.
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Elderly, hypertension, diabetes and cardiovascular diseases are risk factors for COVID-19 morbility and mortality. However, the real reason for this is not yet understood. It is well documented that gut microbiota has a critical role in health, particularly in the immune system and therefore, we propose that gut microbiota composition could affect vulnerability and disease outcomes of COVID-19.
Detailed Description
In order to explore this hypothesis, we will analyse the gut microbiota of SARSCoV-2 infected patients categorized according to location: \[1\] ambulatory (self-isolation at home), \[2\] ward and \[1\] ICU; and severity.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adults of 18 years and above.
- •COVID-19 patients.
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Differences in gut microbiota composition between COVID-19 patients with different degrees of disease severity.
Time Frame: Stool samples of COVID-19 patients will be collected after subject enrollment (single point collection)
Secondary Outcomes
- Differences in gut microbiota composition between COVID-19 patients in relation to mortality.(Through study completion, an average of 3 months.)
- Differences in gut microbiota composition between COVID-19 patients in relation to length of stay in hospitals.(Through study completion, an average of 3 months.)
- Differences in gut microbiota composition between COVID-19 patients in relation to duration of mechanical ventilation.(Through study completion, an average of 3 months.)