Change in Corneal Endothelium After Glaucoma Surgery; Trabeculectomy and Glaucoma Implant Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Glaucoma
- Sponsor
- Chungnam National University
- Enrollment
- 61
- Locations
- 1
- Primary Endpoint
- Change in corneal endothelial cell density, hexagonality, and coefficient of variation of cell area
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this trial is to study the change in corneal endothelial cell after glaucoma surgery, non-contact specular microscopic examination is performed for the patients who underwent glaucoma surgery; trabeculectomy and Ahmed glaucoma valve implant surgery prospectively. Change in corneal endothelial cell density, hexagonality, and coefficient of variation of cell area will be analyzed and compared to the baseline and between the types of the surgeries.
Detailed Description
To study the change in corneal endothelial cell after glaucoma surgery, non-contact specular microscopic examination is performed for the patients who underwent glaucoma surgery; trabeculectomy and Ahmed glaucoma valve implant surgery prospectively. Specular microscopy using non-contact type specular microscope (Noncon Robo SP-8000, Konan Medical Inc., Tokyo, Japan) was performed by one experienced examiner before surgery and 1, 6, 12, 18, and 24 months after surgery. All examinations were done at the center, superior, superonasal, and superotemporal area of the cornea, while the patient maintain fixation at the target in the equipment. The follow-up was stopped if serious complication requiring surgical treatment was developed or additional intraocular pressure lowering surgery is needed, and the data before the second surgery were collected.
Investigators
Chang-sik Kim
professor
Chungnam National University
Eligibility Criteria
Inclusion Criteria
- •Patients who need glaucoma surgery for intraocular pressure control
Exclusion Criteria
- •congenital glaucoma
- •Pre-existing corneal abnormality
- •lost from follow up without any ocular problem within 6 months from surgery
Outcomes
Primary Outcomes
Change in corneal endothelial cell density, hexagonality, and coefficient of variation of cell area
Time Frame: 1 and 2 years longitudinal follow up
Secondary Outcomes
- Clinical factors associated with the damage of corneal endothelium after glaucoma surgery(1 and 2 years longitudinal follow up)