Corneal Endothelium Cell Loss After Cataract Extraction in Patients Taking Systemic Sympathetic Alfa-1-a-antagonist Medication (Tamsulosin)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cataract
- Sponsor
- Frederiksberg University Hospital
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- corneal endothelium cell loss
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
The purpose of this study is to determine whether corneal endothelium cell loss during cataract surgery is higher in patients taking Tamsulosin.
Detailed Description
Cataract surgery in patients taking Tamsulosin is regarded as more challenging for the surgeon because Intraoperative Floppy Iris Syndrome (IFIS) might occur. However, the question is whether this has any practical implication for the outcomes of surgery. In this study we investigate whether cornea is damage during surgery on Tamsulosin patient. In an observational study 30 cataract patients taking Tamsulosin is compared to 30 patients not taking Tamsulosin, but otherwise similar. Number of patients is based on power calculation. Cornea is examined by specular microscopy.
Investigators
Eligibility Criteria
Inclusion Criteria
- •cataract needing surgery
Exclusion Criteria
- •corneal scarring
Outcomes
Primary Outcomes
corneal endothelium cell loss
Time Frame: 3 months
Corneal endothelium cells was evaluated by specular microskopy before and 3 month post-operatively.