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临床试验/NCT03832608
NCT03832608已完成不适用

Relationship Between the Sarcopenia Diagnostic Cut-points and Functionality in Older Adults

University of Valencia1 个研究点 分布在 1 个国家目标入组 300 人开始时间: 2019年1月8日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
300
试验地点
1
主要终点
First criteria of sarcopenia diagnostic: elbow flexion strength

研究概览

简要总结

This is a cross-sectional study conducted in older adults living in Valencia Province in order to establish the cut-off points of the multicriteria diagnostic of sarcopenia through functionality and frailty variables.

详细描述

Sarcopenia is a geriatric syndrome that involves a gradual and generalized loss of the mass and strength of the skeletal muscles. Currently, there is an international debate about the criteria and reference values for the sarcopenia diagnosis, and the main scientific societies encourage improving research on this. The biggest problem lies in the assessment of the diagnostic criterion of muscle mass while the criterion of muscular strength seems safer and more robust. Experts point out the need to adjust the muscle mass indexes to the characteristics of the population studied, and the convenience of relating the three diagnostic criteria of sarcopenia (muscle mass and strength, and walking speed) with other variables that report about functionality and frailty in older adults.

The main objective is to establish different cut-off points for the diagnostic criteria of sarcopenia and relate them with other instruments for assessing functionality in older population of Valencia Province.

To this purpose, data will be collected through various tests and questionnaires about: clinical, demographic and anthropometric characteristics; muscle mass; muscle strength; walk speed; physical and cognitive function; nutritional status; self-perception of health; comorbidity and frailty. With this information it will be possible, as primary outcome, to determine a more sensitive, reliable and valid muscle mass index to predict sarcopenia, and, as a secondary outcome, to establish the relationship between the multicriteria diagnostic of sarcopenia with the functional and frailty variables.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Cross Sectional

入排标准

年龄范围
65 Years 至 —(Older Adult)
性别
All
接受健康志愿者

入选标准

  • People aged > 65 years
  • Residents in Valencia Province (Living-Community, Day-Centers and institutionalized)

排除标准

  • Lobo Mini-exam cognoscitive < 18 score
  • Any disorder that prevents from performing the assessment tests.
  • Recent hospitalization or who are in a acute process of any illness (less one month).

结局指标

主要结局

First criteria of sarcopenia diagnostic: elbow flexion strength

时间窗: The cohort group will be assessed in one day visit.

Muscle strength measured by the isometric elbow flexion (reference: Phys Ther. 1996;76(3):248-59).

Third criteria of sarcopenia diagnostic: walk speed

时间窗: The cohort group will be assessed in one day visit.

Walk speed measured by the Short Physical Performance Balance test (SPPB) (reference: J Gerontol A Biol Sci Med Sc 2000; 55(4):M221-31.

First criteria of sarcopenia diagnostic: knew extension strength

时间窗: The cohort group will be assessed in one day visit.

Muscle strength measured by the isometric knew extension (reference: Phys Ther. 1996;76(3):248-59).

First criteria of sarcopenia diagnostic: hand grip strength

时间窗: The cohort group will be assessed in one day visit.

Muscle strength measured by the isometric hand grip strength (reference: Age and Aging. 2010;39:412-23).

Second criteria of sarcopenia diagnostic: muscle mass

时间窗: The cohort group will be assessed in one day visit.

Muscle mass estimated by Bioimpedance analysis (BIA) (reference: J Aging Phys Act. 2015;23(4):597-606).

次要结局

  • Functionality: Modified Baecke Questionnaire(The cohort group will be assessed in one day visit.)
  • Comorbidity(The cohort group will be assessed in one day visit.)
  • Functionality: Barthel Index(The cohort group will be assessed in one day visit.)
  • Frailty: Fried Scale(The cohort group will be assessed in one day visit.)
  • Functionality: Lawton and Brody Questionnaire(The cohort group will be assessed in one day visit.)
  • Frailty:Frail Scale(The cohort group will be assessed in one day visit.)
  • Frailty: Kihon Check List (KCL)(The cohort group will be assessed in one day visit.)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Maria dels Angels Cebria i Iranzo, PT, PhD

Assistant professor

University of Valencia

研究点 (1)

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