Oxidative Stress in Coronary Artery Surgery

Not Applicable

Recruiting

• Conditions: Post-operative outcomes after Cardiovascular surgery; Post-operative atrial fibrillation; Cardiovascular - Coronary heart disease; Surgery - Other surgery

• Registration Number: ACTRN12612000934842
• Lead Sponsor: Charles McDonald

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-09-03
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Primary CABG
STS score <0.3 or > 2.0

Exclusion Criteria

Pre-operative atrial fibrillation
pacemaker
pre-operative steroids
previous cardiac surgery
off pump surgery
STS score >0.3 <2.0

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
In two different risk groups of patients having coronary artery surgery we will measure selenium levels and oxidative stress markers at various time points to see if an association exists between these markers and the development of post-operative atrial fibrillation. Oxidative stress will be measured by using the lipid peroxidation marker malondialdehyde.[Blood samples at following time points<br><br>Anaesthetic induction<br>Removal of aortic cross clamp<br>3 hours after separation from cardiopulmonary bypass <br>24 hours after separation from cardiopulmonary bypass<br>5 days post-surgery]

Secondary Outcome Measures

Name	Time	Method
Monitoring Lung dysfunction after cardiac surgery (length of mechanical ventilation) and comparing to oxidative stress levels[Time to extubation compared with 24 hr blood sample of oxidative stress];Length of ICU stay versus pre-operative selenium levels[selenium level at Anaesthetic induction]