Maternal-fetal CD4 Microchimerism in HiV Exposed Newborns After Spontaneous Delivery and Cesarean Section
- Conditions
- Human Immunodeficiency Virus
- Registration Number
- NCT01450059
- Lead Sponsor
- Johann Wolfgang Goethe University Hospital
- Brief Summary
The aim of this single centre study is to measure maternal CD4+ t-cells in HiV exposed Newborns after spontaneous birth in comparison to cesarean section.
This may have an influence on the risk of vertical HiV transmission.
- Detailed Description
At birth maternal CD4+ t-cells from umbilical cord blood and placenta blood are measured by microchimerism-analysis.
After 6 weeks the maternal CD4+ t-cells are measured in the blood of the babies blood.
Additionally we look for HiV in maternal CD4+ t-cells.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 54
• HiV exposed Newborns with normal risk of HiV transmission.
- HiV exposed Newborns wiht elevated or high risk of HiV transmission.
- HiV exposed Newborns of mothers not full of age.
- missing informed consent of at least the mother
- Outborns
- Asphyxia
- Major congenital defects
- Chromosomal anomalies
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Maternal CD4+ t-cells in HiV exposed Newborns Six weeks after date of birth The maternal CD4+ t-cells are measured by microchimersimanalysis
- Secondary Outcome Measures
Name Time Method HiV transmission rate 6 month after birth Measurement of HiV PCR at the age of 6 month after birth
Analysis of HiV in maternal CD4+ t-cells 2 month after delivery HiV-PCR analysis from maternal CD4+ cells
Measurement of maternal CD8+ t-cells in the Newborn 6 weeks Measurement of maternal CD8+ t-cells by microchimerismanalysis
Trial Locations
- Locations (1)
Clinic of the Johann Wolfgang-Goethe Univeristy
🇩🇪Frankfurt/Main, Hesse, Germany