Effect of crocin supplementation in treatment of methadone maintenance treatment patients
Phase 2
- Conditions
- Addiction.Other psychoactive substance related disorders
- Registration Number
- IRCT20170420033551N6
- Lead Sponsor
- Kashan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Patients on methadone maintenance treatment
Age of 18 to 70 years old
Evaluated by the drug abuse section of the Structured Clinical Interview for DSM-IV
Seeking for treatment
Exclusion Criteria
Unwillingness to cooperate
Current severe depression and mania
Psychosis
Consumption of crocin, antioxidant, and anti-inflammatory supplements during the last 3 months
High blood pressure
Hypothyroidism or hyperthyroidism
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Craving. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Desire for Drug Questionnaire (DDQ craving).;Withdrawal syndrome. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Clinical opiate withdrawal symptoms (COWS).
- Secondary Outcome Measures
Name Time Method Evaluation of cognitive function. Timepoint: At the baseline and after intervention (12 weeks). Method of measurement: Cognitive function questionnaire.;Verba Fluency. Timepoint: At the baseline and after intervention (12 weeks). Method of measurement: FAS task.;Speed Processing. Timepoint: At the baseline and after intervention (12 weeks). Method of measurement: Digit Symbol and Trial Making Test (TMT).;Memory. Timepoint: At the baseline and after intervention (12 weeks). Method of measurement: Wechsler intelligence Scale (DGSP).