Assessment of Intradialytic Hypertension Management in Adults

Not Applicable

• Conditions: Hypertension; Haemodialysis; Renal and Urogenital - Kidney disease; Cardiovascular - Hypertension

• Registration Number: ACTRN12618000988257
• Lead Sponsor: Richard Singer

Brief Summary

Intradialytic hypertension was identified in 14 patients. After 3 months’ medication/weight adjustment IDH was still present in 10. Of these, 8 consented to a dialysate [Na] adjustment and 7 completed 5 months’ follow-up (1 transferred out of area prior to 5 month followup). The median age of consenting patients was 71 and their mean years spent on dialysis before enrolment was 3.5 years. Dialysate sodium concentration post adjustment was 136mmol/L (range 135 to 141). In those completing 5 months’ follow-up; mean thirst scores improved from 33.3 to 23.6mm (p=0.07), mean plasma sodium concentration fell from 138.1, to 135.3 mmol/L (p=0.05) and IDH was present in only 3 of the 7 patients at 5 months. No adverse events attributable to changes in dialysate sodium were recorded. In 1 patient, dialysate sodium concentration was increased, by the treating physician, from 135 to 140 mmol/L during an admission for diarrhoea.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-06-13
• Study Completion: 2019-05-17
• Last Update Posted: 1 November 2021

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

Patients with a median rise in BP of > 10 mmHg during dialysis over the preceding 2 week period AND an average pre-dialysis systolic BP >115 mmHg.

Exclusion Criteria

Patients with an average pre-dialysis systolic BP <=115 mmHg over the preceding 2 weeks.

Study & Design

• Study Type: Observational
• Study Design: Not specified